Evaluating the Effect of Injectable Platelet-rich Fibrin on Accelerating Orthodontic Tooth Movement

Last updated: September 9, 2025
Sponsor: Hama University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Periodontitis

Treatment

injectable form of PRF

Placebo injection

Clinical Study ID

NCT06302296
Hama University/
  • Ages 18-26
  • All Genders

Study Summary

One of the main goals of orthodontic treatment is the reduction of treatment time through faster tooth movement. The previous studies evaluating platelet-rich fibrin (PRF) and orthodontic tooth movement (OTM) are limited, which makes the results difficult to generalize.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • The patient's age (18-26). Severe or very severe irregularity of the upper incisorsgreater than (7 mm) according to Little's index, so it is recommended to extract theupper first premolar.

  • Class I or Class II malocclusion, first model according to Angle, with skeletalclass I or II and a normal or mild vertical growth pattern.

  • All permanent upper teeth, up to the first molar, are present, with thepossibility of attaching brackets to all teeth in a correct position.

  • The patient has good oral health.

Exclusion

Exclusion Criteria:

  • • The presence of any systemic disease that affects orthodontic dental movement.

  • Severe malalignment of one of the teeth (palatal quadrant, ectopic canine,ectopic premolar).

  • The patient has undergone previous orthodontic treatment.

  • The patient is subject to any drug treatment that may affect orthodontic dentalmovement (cortisone, non-steroidal anti-inflammatory drugs).

  • The patient has poor oral health.

  • Commitment to periodic follow-up appointments.

Study Design

Total Participants: 14
Treatment Group(s): 2
Primary Treatment: injectable form of PRF
Phase:
Study Start date:
December 20, 2025
Estimated Completion Date:
July 15, 2026

Study Description

One of the main goals of orthodontic treatment is the reduction of treatment time through faster tooth movement. The previous studies evaluating platelet-rich fibrin (PRF) and orthodontic tooth movement (OTM) are limited, which makes the results difficult to generalize. To this end, we set up this Randomized experiment to evaluate the effect of the injectable form of PRF (i-PRF) on OTM, using nonadditive containing i-PRF, which has higher levels of regenerative cells and growth factors compared with other PRF types because of the use of low centrifugation spee. Accordingly, we aimed to evaluate the effect of i-PRF on the rate of maxillary incisors leveling during comprehensive orthodontic treatment.

Connect with a study center

  • Fadi Jnaid

    Hama 170017,
    Syria

    Active - Recruiting

  • Fadi Jnaid

    Hama,
    Syrian Arab Republic

    Site Not Available

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