Stellate Ganglion Block for Preserving Arteriovenous Fistula in Hemodialysis Patients Undergoing Major Lower Limb Orthopedic Surgery

Last updated: February 26, 2025
Sponsor: Aswan University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Hemodialysis

Treatment

Stellate ganglion block

Clinical Study ID

NCT06300658
900/2/24
  • Ages 21-75
  • All Genders

Study Summary

The aim of this study is to evaluate the role of stellate ganglion blockade (SGB) for preserving arteriovenous fistula in hemodialysis patients undergoing major lower limb orthopedic surgery.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age 21 to 75 years.

  • Both sexes.

  • American Society of Anesthesiologists (ASA) physical status III.

  • Chronic renal failure (CRF) patients.

  • Undergoing major lower limb orthopedic surgery.

Exclusion

Exclusion Criteria:

  • Psychiatric disorders.

  • History of substance abuse.

  • Ipsilateral brachial and radial artery stenosis.

  • Allergy to local anesthetics.

  • Cardiovascular and respiratory disorders.

  • Coagulopathy.

  • Use of vasoactive medications.

  • Obesity (body mass index >30 kg/m2).

  • Smoking.

Study Design

Total Participants: 50
Treatment Group(s): 1
Primary Treatment: Stellate ganglion block
Phase:
Study Start date:
March 09, 2024
Estimated Completion Date:
February 28, 2025

Study Description

The best way for dialysis in chronic renal failure (CRF) patients with consideration of feasibility, rate of infection, and patency is hemodialysis by using native access by using arteriovenous fistula (AVF).

Altered calcium and phosphor metabolism in CRF patients would also increase vascular reactivity. Stellate ganglion blockade (SGB) has been used for several years for both diagnosis and treatment of circulatory problems in upper extremity. Recently preemptive SGB has been used in prevention of radial artery spasm in coronary artery patients.

SGB increases blood flow and decrease vascular resistance in the arm. SGB prevents or ameliorates the reactivity of the muscular layer of the RA in response to both surgical manipulation during harvesting the artery and to the potent vasoconstrictor mediators released during surgery

Connect with a study center

  • Aswan University

    Aswan, 81528
    Egypt

    Active - Recruiting

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