Brain Connectivity Measured With High-density Electroencephalography

Last updated: March 1, 2024
Sponsor: IRCCS San Camillo, Venezia, Italy
Overall Status: Active - Recruiting

Phase

N/A

Condition

Stroke

Cerebral Ischemia

Treatment

Connectivity measures

Clinical Study ID

NCT06298097
2019.11
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Emerging scientific results show that disrupted functional connectivity in stroke can explain behavioral impairments and predict their recovery over time. However, no technique is yet available for widespread use in clinics to examine how neural synchronization in brain networks is altered in stroke patients. This is crucial to determine favorable prognostic factors and to define individualized rehabilitation protocols. Importantly, the investigators have successfully used high-density electroencephalography (hdEEG) in healthy individuals to measure neural synchronization in brain networks. In this project, the investigators will develop methods and tools based on hdEEG for assessing functional connectivity in stroke patients. These methods and tools will be employed to examine how neural changes occurring after brain lesions explain behavioral impairments. The project will open the way for the use of hdEEG at the patient's bedside, as a neurodiagnostic tool for stroke as well as other brain disorders.

Eligibility Criteria

Inclusion

In this study 125 stroke patients and 45 healthy participants will be recruited at the Institute for Research and Healthcare with a Scientific Character (IRCCS) San Camillo hospital.

Inclusion Criteria (patients):

  • right or left hemisphere damage

  • unilateral stroke

  • compliance with magnetic resonance imaging (e.g., no claustrophobia)

Inclusion Criteria (healthy participants):

• compliance with magnetic resonance imaging (e.g., no claustrophobia)

Exclusion Criteria (both patients and healthy participants):

• no comorbidities with psychiatric disorders

Study Design

Total Participants: 170
Treatment Group(s): 1
Primary Treatment: Connectivity measures
Phase:
Study Start date:
June 11, 2020
Estimated Completion Date:
February 02, 2025

Connect with a study center

  • IRCCS San Camillo Hospital

    Venice,
    Italy

    Active - Recruiting

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