Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)

Inclusion Criteria:

• Have Type 2 Diabetes (T2D)

• Have HbA1c ≥7.0% (53 millimoles per mole (mmol/mol)) to ≤10.5% (91 mmol/mol)

• Have moderate or severe renal impairment

• Have been on the following stable diabetes treatment during 90 days prior toscreening

• basal insulin (≥20 International Units (IU)/day) with or without

• metformin and/or SGLT2 inhibitor

• Are of stable weight for at least 90 days prior to screening

• Have a Body Mass Index (BMI) ≥23.0 kilograms per meter squared (kg/m2)

Exclusion Criteria:

• Have Type 1 Diabetes (T1D)

• Have a history of ketoacidosis or hyperosmolar state or coma within the last 6months prior to screening

• Have a history of severe hypoglycemia or hypoglycemia unawareness within the last 6months prior to screening

• Are currently receiving or planning to receive treatment for diabetic retinopathyand/or macular edema

• Have a history of unstable or rapidly progressing renal disease

• Have a prior or planned surgical treatment for obesity

• Have New York Heart Association Functional Classification III or IV congestive heartfailure

• Have had acute myocardial infarction, stroke, or were hospitalized for congestiveheart failure within 90 days prior to screening

• Have a known clinically significant gastric emptying abnormality

• Have a history of an active or untreated malignancy or are in remission from aclinically significant malignancy for less than 5 years

• Have a family or personal history of medullary thyroid carcinoma or multipleendocrine neoplasia (MEN) syndrome Type 2.

• Have any lifetime history of a suicide attempt

• Had chronic or acute pancreatitis

• Have taken prescribed or over-the-counter medication, or alternative remedies,intended to promote body weight reduction within 90 days prior to screening