A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease

Inclusion Criteria:

• Have a body mass index (BMI) within the range 18 to 40 kilograms per square meter (kg/m²), inclusive, at screening.

• Have gradual and progressive change in memory function for greater than or equal to (≥) 6 months as reported by the participant or informant.

• Have a mini mental state examination (MMSE) score of 18 to 30 at screening.

• Have a clinical dementia rating (CDR) global score of 0.5 to 1.0, with a memory boxscore ≥ 0.5 at screening.

• Meet flortaucipir F18 positron emission tomography (PET) criteria, as defined in theTAUVID™ FDA label (TAUVID™ prescribing information, 2024), demonstrating evidence oftau pathology.

• Males who agree to follow contraceptive requirements, or women not of childbearingpotential (WNOCBP).

• Participants must have up to 2 study partners who are with contact with theparticipant at least 10 hours per week and one of whom can attend studyappointments.

Exclusion Criteria:

• Has current serious or unstable illnesses including cardiovascular, hepatic, renal,gastroenterological, respiratory, endocrinologic, neurologic (other than Alzheimer'sDisease), psychiatric, immunologic, or hematologic disease and other conditionsthat, in the investigator's opinion, could interfere with the analyses in thisstudy; or has a life expectancy of less than (<)24 months.

• Have a sensitivity to flortaucipir F18.

• Have contraindication to magnetic resonance imaging (MRI), including claustrophobiaor the presence of contraindicated metal (ferromagnetic) implants/cardiac pacemaker.

• Have a current exposure to an amyloid targeted therapy (ATT). Prior exposure to ATTsgreater than 1 year from the last dose may be permitted at the discretion of theinvestigator and in consultation with the sponsor.

• Have previous exposure to any Investigational Medicinal Product administeredintrathecal (IT) or previous exposure to any anti-tau therapy.

• Have a history of clinically significant back pain, back pathology and/or backinjury (for example, degenerative disease, spinal deformity or spinal surgery) thatmay predispose to complications or technical difficulty with lumbar puncture.