A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease

Last updated: April 23, 2025
Sponsor: AstraZeneca
Overall Status: Active - Recruiting

Phase

3

Condition

Copd (Chronic Obstructive Pulmonary Disease)

Treatment

GFF MDI 14.4/9.6 μg

BGF MDI 320/14.4/9.6 μg

Clinical Study ID

NCT06283966
D5989C00001
2023-507407-59-00
  • Ages 40-80
  • All Genders

Study Summary

This study will evaluate the effect of triple ICS/LAMA/LABA therapy with BGF MDI 320/14.4/9.6 μg on cardiopulmonary outcomes relative to LAMA/LABA therapy with GFF MDI 14.4/9.6 μg in a population with COPD and elevated cardiopulmonary risk.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Male or female participants must be 40 to 80 years of age inclusive, at the time ofsigning the ICF.

  2. Demonstrate acceptable MDI administration technique at Visit 1 (V1) and Visit 2 (V2)

  3. A diagnosis of COPD confirmed by a post-bronchodilator FEV1/FVC ratio < 70% at V1.

  4. Current or former smokers with a history of at least 10 pack-years of cigarettesmoking; defined as (number of cigarettes per day/20) x number of years smoked. Previoussmokers are defined as those who have stopped smoking for at least 6 months prior to V1.

  5. A baseline peripheral blood eosinophil count of ≥ 100 cells/mm3 assessed at Visit 1by the central laboratory

  6. A CAT score of ≥ 10 at Visit 1.

  7. Participant must fulfill at least 1 of the 4 CV disease/risk factor criteria below [(a), (b),

(c), or (d)]:

  1. : Established CV Disease

  2. : Combination of CV risk factors:

  • Hypertension
  • Diabetes Mellitus
  • Chronic Kidney Disease
  • Dyslipidemia
  • Obesity

  1. : High risk of CV disease determined using an established CV risk assessmenttool.

  2. : CT coronary Artery Calcification

  3. Willing and, in the opinion of the investigator, able to adjust current COPDtherapy, as required by the protocol.

  4. Willing to visit at the study site or participate in virtual visits as required perthe protocol to complete all study assessments.

  5. A female is eligible to enter and participate in the study if the female is of:

  • Non-childbearing potential: either permanently sterilized or who arepost-menopausal.

  • Childbearing potential: has a negative serum pregnancy test at V1 and must useone highly effective form of birth control.

  1. Capable of giving signed informed consent, which includes compliance with therequirements and restrictions listed in the ICF and in the protocol.

Exclusion

Exclusion Criteria:

  1. Active diagnosis of asthma within the past 5 years (previous diagnosis as a child oradolescent are eligible), asthma-COPD overlap, or any other chronic respiratorydisease other than COPD such as alpha-1 antitrypsin deficiency, active tuberculosis,lung fibrosis, sarcoidosis, interstitial lung disease, and pulmonary hypertension.

  2. End-stage renal disease requiring renal replacement therapy

  3. History of heart or lung transplant or actively listed for heart or lung transplant.

  4. Implanted left ventricular assist device or implant anticipated in < 3 months.

  5. History of lung cancer and/or treatment for lung cancer within the 5 years prior toVisit 1.

  6. Unstable or life-threatening cardiac disease - participants with any of thefollowing at Visit 1 would be excluded:

  7. An MI or unstable angina in the last 8 weeks

  8. Unstable or life-threatening cardiac arrhythmia requiring intervention in thelast 8 weeks. NOTE: Any participant who experiences unstable or life-threatening cardiac diseaseduring the run-in period will be excluded but can be rescreened 8 weeks after theresolution of the event.

  9. Pneumonia and/or moderate or severe COPD exacerbation that has not resolved at least 8 weeks prior to Visit 1

  10. Any life-threatening condition, including malignancy, with a life expectancy < 5years, other than CV disease or COPD, that might prevent the participant fromcompleting the study.

  11. Use of maintenance ICS treatment within the past 12 months.

  12. Unable to abstain from protocol-defined prohibited medications

  13. Participation in another clinical study with a study intervention administered inthe last 30 days or 5 half-lives, whichever is longer prior to Visit 1 (any otherinvestigational product that is not identified in protocol is prohibited for useduring the duration of the study).

  14. Participants with a known hypersensitivity to LAMA, LABA or ICS or any component ofthe MDI.

  15. Involvement in the planning and/or conduct of the study (applies to both AstraZenecastaff and/or staff at the study site).

  16. Judgment by the investigator that the participant should not participate in thestudy if the participant is unlikely to comply with study procedures, restrictions,and requirements.

  17. Previous randomization in the present study.

  18. For females only - currently pregnant (confirmed with positive pregnancy test) orbreastfeeding

Study Design

Total Participants: 5000
Treatment Group(s): 2
Primary Treatment: GFF MDI 14.4/9.6 μg
Phase: 3
Study Start date:
February 21, 2024
Estimated Completion Date:
March 07, 2028

Study Description

This is a Phase III randomized, double-blind, parallel group, multi-center event-driven study comparing BGF MDI 320/14.4/9.6 μg BID with GFF MDI 14.4/9.6 μg BID in participants with COPD who are at risk of a cardiopulmonary event.

Connect with a study center

  • Research Site

    Buenos Aires, 1425
    Argentina

    Active - Recruiting

  • Research Site

    Caba, C1019ABS
    Argentina

    Active - Recruiting

  • Research Site

    Capital Federal, C1060ABN
    Argentina

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    Ciudad Autónomas De Buenos Aires, 1425
    Argentina

    Site Not Available

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    Florencio Varela, 1888
    Argentina

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    Florida, B1602DQD
    Argentina

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    Mar del Plata, B7600GWV
    Argentina

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    Mendoza, M5500GIP
    Argentina

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    Ranelagh, 1886
    Argentina

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    Rosario, 2000
    Argentina

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    San Fernando, B1646EBJ
    Argentina

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    San Miguel de Tucumán, T4000CBC
    Argentina

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    Tucumán, 4000
    Argentina

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    Birtinya, 4575
    Australia

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    Cairns, 4870
    Australia

    Site Not Available

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    Chermside, 4032
    Australia

    Completed

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    Coffs Harbour, 02450
    Australia

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    Dubbo, 2830
    Australia

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    Nedlands, 6009
    Australia

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    Port Macquarie, 2444
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    Site Not Available

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    Spearwood, 6163
    Australia

    Completed

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    St Albans, 3021
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    Taringa, 4068
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    Wangaratta, 3677
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    Bad Ischl, 4820
    Austria

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    Braunau, 5280
    Austria

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    Feldbach, 8330
    Austria

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    Graz, 8036
    Austria

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    Wien, 1090
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    Belo Horizonte, 30110-934
    Brazil

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    Blumenau, 89030-101
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    Brasilia, 71681-603
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    Campina Grande do Sul, 83.430-000
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    Campinas, 13060-080
    Brazil

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    Caxias do Sul, 95070-560
    Brazil

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    Curitiba, 80810-050
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    Fortaleza, 60125-025
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    Ijui, 98700-000
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    Juiz de Fora, 36033-318
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    Mossoro, 59603-020
    Brazil

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    Natal, 59020-035
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    Niterói, 24020-096
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    Passo Fundo, 99010-120
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    Porto Alegre, 9061-000
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    Recife, 50740-465
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    Rio de Janeiro, 22281-100
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    Salvador, 40170-130
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    Santo Andre, 09080-110
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    Sao Bernardo do Campo, 09750-420
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    Sao Jose Do Rio Preto, 15090-000
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    Sao Paulo, 05403-000
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    Serra, 29160-750
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    Sorocaba, 18040-425
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    São Paulo, 04012-180
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    Volta Redonda, 27258-000
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    Votuporanga, 15501-405
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    Burgas, 8000
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    Dobrich, 9300
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    Dupnitsa, 2600
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    Haskovo, 6300
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    Kozloduy, 3320
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    Montana, 3400
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    Panagyurishte, 4500
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    Pazardzhik, 4400
    Bulgaria

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    Pleven, 5800
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    Plovdiv, 4004
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    Ruse, 7002
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    Sandanski, 2800
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    Sliven, 8800
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    Sofia, 1202
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    Varna, 9000
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    Vratsa, 3000
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    Yambol, 8600
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    Curico, 3341643
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    Beijing, 101100
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    Changsha, 410005
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    Changzhi, 46000
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    Chengdu, 611130
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    Chifeng, 024000
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    Chizhou, 247099
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    Chongqing, 408400
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    Daqing, 163000
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    Dazhou, 635000
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    Foshan, 528000
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    Fuzhou, 350001
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    Haikou, 570311
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    Lanzhou, 730000
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    Lishui, 323000
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    Liuzhou, 545006
    China

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    Nanchang, 330006
    China

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    Nanjing, 210009
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    Pingxiang, 337055
    China

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    Qingdao, 266011
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    Qingyuan, 511518
    China

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    Ruian, 325299
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    Sanya, 572000
    China

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    Shanghai, 201199
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    Shaoxing, 312000
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    Shenyang, 110032
    China

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    Shenzhen, 518020
    China

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    Shihezi, 832008
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    Shijiazhuang, 50051
    China

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    Siping, 136000
    China

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    Suining Shi, 629000
    China

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    Taicang, 215400
    China

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    Taiyuan, 030001
    China

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    Taizhou, 318000
    China

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    Urumqi, 831118
    China

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    WeiFang, 261000
    China

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    Wenzhou, 325027
    China

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    Xi'an, 710006
    China

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    Xiamen, 361004
    China

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    Xiangtan, 411100
    China

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    Xianyang, 750004
    China

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    Xingtai, 054899
    China

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    Xinxiang, 453002
    China

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    Xuzhou, 221009
    China

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    Yangzhou, 225001
    China

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    Yinchuan, 750001
    China

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    Zaozhuang City, 277102
    China

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    Zhangzhou, 363099
    China

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    Zhengzhou, 450006
    China

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    Zhuhai, 519099
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    Zhumadian, 463000
    China

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    Zhuzhou, 412007
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    Zigong, 643000
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    Armenia, 630004
    Colombia

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    Barranquilla, 080020
    Colombia

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    Bogota, 111411
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    Manizales, 17001
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    Medellin, 050025
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    Piedecuesta, 681017
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    Rionegro, 054047
    Colombia

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    Brandys nad Labem, 250 01
    Czechia

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    Olomouc, 772 00
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    Ostrava, 702 00
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    Praha 1, 110 00
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    Aalborg, 9000
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    Esbjerg, 6700
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    Næstved, 4700
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    Vejle, 7100
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    Helsinki, 00180
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    Kuopio, 70100
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    Turku, 20100
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    France

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    Aurillac Cedex, 15002
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    Brest, 29200
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    Brest Cedex, 29609
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    Cannes, 06414
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    La Tronche, 38700
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    Le Coudray Cedex, 28630
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    Lomme, Cedex 59462
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    Lyon Cedex 04, 69317
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    Marseille, 13003
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    Mulhouse, 68100
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    Paris, 75651
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    France

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    Pringy Cedex, 74374
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    Roscoff, 29680
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    Strasbourg Cedex, 67091
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    VANNES cedex, 56017
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    Vandoeuvre-Les-Nancy Cedex, 54511
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    Villeurbanne, 69100
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    Ahrensburg, 22926
    Germany

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    Augsburg, 86150
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    Dachau, 85221
    Germany

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    Germany

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    Dresden, 01069
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    Germany

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    Frankfurt, 60596
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    Germany

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    Germany

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    Ahmedabad, 380015
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    Korea, Republic of

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    Korea, Republic of

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    Norway

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    Norway

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    Norway

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    Philippines

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    Philippines

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    Philippines

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    Philippines

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    Bialystok, 15-879
    Poland

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    Romania

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    Romania

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    Romania

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    Serbia

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    Serbia

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    Serbia

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    Slovakia

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    Slovakia

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    Spain

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    Spain

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    Spain

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    Spain

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    Spain

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    Spain

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    Spain

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    Spain

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    Spain

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    Spain

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    Spain

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    Spain

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    Spain

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    Spain

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    Spain

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    Spain

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    Sweden

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    Höllviken, 236 51
    Sweden

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    Sweden

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    Sweden

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    Sweden

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    Sweden

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    Sweden

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    Taiwan

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    Taiwan

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    Taiwan

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    Taiwan

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    Taiwan

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    Taiwan

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    Taiwan

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    Taiwan

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    Taiwan

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    Thailand

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    Thailand

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    Thailand

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    Thailand

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    Thailand

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    Thailand

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    Phitsanulok, 65000
    Thailand

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    Thailand

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    Turkey

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    Turkey

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    Turkey

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    Turkey

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    Turkey

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    Turkey

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    Turkey

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    Turkey

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    Turkey

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    Kocaeli, 41380
    Turkey

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    Turkey

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    Tekirdag, 59030
    Turkey

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    Turkey

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    Turkey

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    Turkey

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    Ukraine

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    Ukraine

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    Ukraine

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    Ukraine

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    Ukraine

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    Ukraine

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    Ukraine

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    United Kingdom

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    United Kingdom

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    United Kingdom

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    United Kingdom

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    United Kingdom

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    United Kingdom

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    United Kingdom

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    United Kingdom

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    United Kingdom

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    United Kingdom

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    United Kingdom

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    United Kingdom

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    United Kingdom

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    United Kingdom

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    United Kingdom

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    United Kingdom

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    United Kingdom

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    United Kingdom

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    United Kingdom

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    United Kingdom

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    United Kingdom

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    United Kingdom

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    United Kingdom

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    Whitney, OX29 4QB
    United Kingdom

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    United Kingdom

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    Athens, Alabama 35611
    United States

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    United States

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    Fairhope, Alabama 36532
    United States

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    Huntsville, Alabama 35801
    United States

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    United States

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    United States

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    United States

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    United States

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    United States

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    United States

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    United States

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    United States

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    United States

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    United States

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    United States

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    United States

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    United States

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    United States

    Terminated

  • Research Site

    Inglewood, California 90301
    United States

    Active - Recruiting

  • Research Site

    La Mesa, California 91942
    United States

    Active - Recruiting

  • Research Site

    La Palma, California 90623
    United States

    Active - Recruiting

  • Research Site

    Lomita, California 90717
    United States

    Active - Recruiting

  • Research Site

    Long Beach, California 90815
    United States

    Active - Recruiting

  • Research Site

    Los Alamitos, California 90720
    United States

    Terminated

  • Research Site

    Newport Beach, California 92663
    United States

    Active - Recruiting

  • Research Site

    North Hollywood, California 91602
    United States

    Terminated

  • Research Site

    Panorama City, California 91402
    United States

    Site Not Available

  • Research Site

    Pomona, California 91768
    United States

    Active - Recruiting

  • Research Site

    Sacramento, California 95831
    United States

    Active - Recruiting

  • Research Site

    Salinas, California 93901
    United States

    Site Not Available

  • Research Site

    San Bernardino, California 92408
    United States

    Terminated

  • Research Site

    San Diego, California 92111
    United States

    Active - Recruiting

  • Research Site

    San Dimas, California 91773
    United States

    Site Not Available

  • Research Site

    Santa Ana, California 92704
    United States

    Site Not Available

  • Research Site

    Tarzana, California 91356
    United States

    Active - Recruiting

  • Research Site

    Thousand Oaks, California 91360
    United States

    Active - Recruiting

  • Research Site

    Van Nuys, California 91405
    United States

    Site Not Available

  • Research Site

    Vista, California 92081
    United States

    Active - Recruiting

  • Research Site

    Westminster, California 92683
    United States

    Active - Recruiting

  • Research Site

    Aurora, Colorado 80012
    United States

    Active - Recruiting

  • Research Site

    Denver, Colorado 80228
    United States

    Active - Recruiting

  • Research Site

    Englewood, Colorado 80110
    United States

    Active - Recruiting

  • Research Site

    Washington, District of Columbia 20016
    United States

    Terminated

  • Research Site

    Boynton Beach, Florida 33435
    United States

    Active - Recruiting

  • Research Site

    Bradenton, Florida 34209
    United States

    Active - Recruiting

  • Research Site

    Cape Coral, Florida 33990
    United States

    Active - Recruiting

  • Research Site

    Clearwater, Florida 33765
    United States

    Active - Recruiting

  • Research Site

    Crystal River, Florida 34429
    United States

    Active - Recruiting

  • Research Site

    Cutler Bay, Florida 33189
    United States

    Active - Recruiting

  • Research Site

    Edgewater, Florida 32132
    United States

    Active - Recruiting

  • Research Site

    Fort Lauderdale, Florida 33308
    United States

    Active - Recruiting

  • Research Site

    Fort Myers, Florida 33912
    United States

    Active - Recruiting

  • Research Site

    Hialeah, Florida 33013
    United States

    Active - Recruiting

  • Research Site

    Hollywood, Florida 33024
    United States

    Active - Recruiting

  • Research Site

    Homestead, Florida 33032
    United States

    Active - Recruiting

  • Research Site

    Kissimmee, Florida 34741
    United States

    Site Not Available

  • Research Site

    Lake City, Florida 32055
    United States

    Active - Recruiting

  • Research Site

    Lake Worth, Florida 33467
    United States

    Active - Recruiting

  • Research Site

    Lakeland, Florida 33805
    United States

    Active - Recruiting

  • Research Site

    Loxahatchee Groves, Florida 33470
    United States

    Site Not Available

  • Research Site

    Miami, Florida 33155
    United States

    Active - Recruiting

  • Research Site

    Miami Lakes, Florida 33014
    United States

    Active - Recruiting

  • Research Site

    Naples, Florida 34102
    United States

    Active - Recruiting

  • Research Site

    Ocala, Florida 34470
    United States

    Active - Recruiting

  • Research Site

    Orlando, Florida 32807
    United States

    Active - Recruiting

  • Research Site

    Ormond Beach, Florida 32174
    United States

    Active - Recruiting

  • Research Site

    Pembroke Pines, Florida 33024
    United States

    Active - Recruiting

  • Research Site

    Plantation, Florida 33324
    United States

    Active - Recruiting

  • Research Site

    Saint Petersburg, Florida 33713
    United States

    Active - Recruiting

  • Research Site

    Sun City Center, Florida 33573
    United States

    Active - Recruiting

  • Research Site

    Tamarac, Florida 33321
    United States

    Active - Recruiting

  • Research Site

    Tampa, Florida 33606
    United States

    Active - Recruiting

  • Research Site

    Atlanta, Georgia 30349
    United States

    Active - Recruiting

  • Research Site

    Buford, Georgia 30519
    United States

    Site Not Available

  • Research Site

    Peachtree Corners, Georgia 30092
    United States

    Site Not Available

  • Research Site

    Savannah, Georgia 31406
    United States

    Active - Recruiting

  • Research Site

    Tucker, Georgia 30084
    United States

    Active - Recruiting

  • Research Site

    Boise, Idaho 83706
    United States

    Terminated

  • Research Site

    Chicago, Illinois 60607
    United States

    Active - Recruiting

  • Research Site

    Downers Grove, Illinois 60515
    United States

    Site Not Available

  • Research Site

    Winfield, Illinois 60190
    United States

    Active - Recruiting

  • Research Site

    Valparaiso, Indiana 46383
    United States

    Active - Recruiting

  • Research Site

    Sioux City, Iowa 51106
    United States

    Active - Recruiting

  • Research Site

    Newton, Kansas 67114
    United States

    Active - Recruiting

  • Research Site

    Wichita, Kansas 67218
    United States

    Active - Recruiting

  • Research Site

    Lexington, Kentucky 40503
    United States

    Active - Recruiting

  • Research Site

    Paducah, Kentucky 42001
    United States

    Active - Recruiting

  • Research Site

    Lafayette, Louisiana 70508
    United States

    Active - Recruiting

  • Research Site

    Monroe, Louisiana 71201
    United States

    Active - Recruiting

  • Research Site

    Shreveport, Louisiana 71105
    United States

    Active - Recruiting

  • Research Site

    Zachary, Louisiana 70791
    United States

    Active - Recruiting

  • Research Site

    Glen Burnie, Maryland 21061
    United States

    Site Not Available

  • Research Site

    Oxon Hill, Maryland 20745
    United States

    Active - Recruiting

  • Research Site

    Potomac, Maryland 20854
    United States

    Terminated

  • Research Site

    Boston, Massachusetts 02115
    United States

    Active - Recruiting

  • Research Site

    Ann Arbor, Michigan 48109
    United States

    Active - Recruiting

  • Research Site

    Flint, Michigan 48504
    United States

    Active - Recruiting

  • Research Site

    Lathrup Village, Michigan 48076
    United States

    Site Not Available

  • Research Site

    Southfield, Michigan 48075
    United States

    Active - Recruiting

  • Research Site

    Gulfport, Mississippi 39503
    United States

    Active - Recruiting

  • Research Site

    Olive Branch, Mississippi 38654
    United States

    Active - Recruiting

  • Research Site

    Kansas City, Missouri 64116
    United States

    Active - Recruiting

  • Research Site

    Liberty, Missouri 64068
    United States

    Site Not Available

  • Research Site

    Saint Louis, Missouri 63104
    United States

    Active - Recruiting

  • Research Site

    Missoula, Montana 59808
    United States

    Active - Recruiting

  • Research Site

    Fremont, Nebraska 68025
    United States

    Active - Recruiting

  • Research Site

    Grand Island, Nebraska 68803
    United States

    Active - Recruiting

  • Research Site

    Lincoln, Nebraska 68510
    United States

    Site Not Available

  • Research Site

    Omaha, Nebraska 68134
    United States

    Active - Recruiting

  • Research Site

    Las Vegas, Nevada 89101
    United States

    Active - Recruiting

  • Research Site

    Lawrence Township, New Jersey 08648
    United States

    Site Not Available

  • Research Site

    Mullica Hill, New Jersey 08062
    United States

    Active - Recruiting

  • Research Site

    Toms River, New Jersey 08755
    United States

    Active - Recruiting

  • Research Site

    Union City, New Jersey 07087
    United States

    Site Not Available

  • Research Site

    Albuquerque, New Mexico 87109
    United States

    Site Not Available

  • Research Site

    Albany, New York 12208
    United States

    Site Not Available

  • Research Site

    Bronx, New York 10455
    United States

    Active - Recruiting

  • Research Site

    Bronxville, New York 10708
    United States

    Site Not Available

  • Research Site

    Brooklyn, New York 11220
    United States

    Active - Recruiting

  • Research Site

    Massapequa, New York 11758
    United States

    Active - Recruiting

  • Research Site

    New Windsor, New York 12553
    United States

    Active - Recruiting

  • Research Site

    New York, New York 10036
    United States

    Active - Recruiting

  • Research Site

    Vestal, New York 13850
    United States

    Terminated

  • Research Site

    Fayetteville, North Carolina 28303
    United States

    Terminated

  • Research Site

    Greensboro, North Carolina 27405
    United States

    Active - Recruiting

  • Research Site

    Greenville, North Carolina 27834
    United States

    Active - Recruiting

  • Research Site

    Huntersville, North Carolina 28078
    United States

    Active - Recruiting

  • Research Site

    Morehead City, North Carolina 28557
    United States

    Active - Recruiting

  • Research Site

    Raleigh, North Carolina 27612
    United States

    Active - Recruiting

  • Research Site

    Salisbury, North Carolina 28144
    United States

    Terminated

  • Research Site

    Statesville, North Carolina 28625
    United States

    Active - Recruiting

  • Research Site

    Wilmington, North Carolina 28401
    United States

    Active - Recruiting

  • Research Site

    Winston-Salem, North Carolina 27104
    United States

    Active - Recruiting

  • Research Site

    Beavercreek, Ohio 45431
    United States

    Active - Recruiting

  • Research Site

    Blue Ash, Ohio 45242
    United States

    Active - Recruiting

  • Research Site

    Cleveland, Ohio 44130
    United States

    Active - Recruiting

  • Research Site

    Columbus, Ohio 43215
    United States

    Active - Recruiting

  • Research Site

    Marion, Ohio 43302
    United States

    Active - Recruiting

  • Research Site

    Toledo, Ohio 43617
    United States

    Site Not Available

  • Research Site

    Norman, Oklahoma 73071
    United States

    Active - Recruiting

  • Research Site

    Oklahoma City, Oklahoma 73134
    United States

    Active - Recruiting

  • Research Site

    Tulsa, Oklahoma 74133
    United States

    Active - Recruiting

  • Research Site

    Grants Pass, Oregon 97527
    United States

    Active - Recruiting

  • Research Site

    Medford, Oregon 97504
    United States

    Active - Recruiting

  • Research Site

    Roseburg, Oregon 97471
    United States

    Site Not Available

  • Research Site

    Camp Hill, Pennsylvania 17011
    United States

    Active - Recruiting

  • Research Site

    DuBois, Pennsylvania 15801
    United States

    Site Not Available

  • Research Site

    Exton, Pennsylvania 19341
    United States

    Site Not Available

  • Research Site

    Newport, Pennsylvania 17011
    United States

    Site Not Available

  • Research Site

    Philadelphia, Pennsylvania 19140
    United States

    Active - Recruiting

  • Research Site

    Anderson, South Carolina 29621
    United States

    Active - Recruiting

  • Research Site

    Charleston, South Carolina 29414
    United States

    Terminated

  • Research Site

    Columbia, South Carolina 29201
    United States

    Site Not Available

  • Research Site

    Gaffney, South Carolina 29340
    United States

    Active - Recruiting

  • Research Site

    Spartanburg, South Carolina 29303
    United States

    Active - Recruiting

  • Research Site

    Union, South Carolina 29379
    United States

    Active - Recruiting

  • Research Site

    North Sioux City, South Dakota 57049
    United States

    Site Not Available

  • Research Site

    Pierre, South Dakota 57501
    United States

    Site Not Available

  • Research Site

    Rapid City, South Dakota 57701
    United States

    Active - Recruiting

  • Research Site

    Sioux Falls, South Dakota 57104
    United States

    Active - Recruiting

  • Research Site

    Chattanooga, Tennessee 37421
    United States

    Active - Recruiting

  • Research Site

    Elizabethton, Tennessee 37643
    United States

    Terminated

  • Research Site

    Franklin, Tennessee 37067
    United States

    Active - Recruiting

  • Research Site

    Morristown, Tennessee 37813
    United States

    Terminated

  • Research Site

    Tullahoma, Tennessee 37388
    United States

    Active - Recruiting

  • Research Site

    Abilene, Texas 79606
    United States

    Active - Recruiting

  • Research Site

    Amarillo, Texas 79106
    United States

    Site Not Available

  • Research Site

    Austin, Texas 78704
    United States

    Terminated

  • Research Site

    Brownsville, Texas 78520
    United States

    Active - Recruiting

  • Research Site

    Dallas, Texas 75235
    United States

    Active - Recruiting

  • Research Site

    Denison, Texas 75020
    United States

    Site Not Available

  • Research Site

    El Paso, Texas 79902
    United States

    Active - Recruiting

  • Research Site

    Forney, Texas 75126
    United States

    Active - Recruiting

  • Research Site

    Georgetown, Texas 78633
    United States

    Active - Recruiting

  • Research Site

    Houston, Texas 77207
    United States

    Terminated

  • Research Site

    Katy, Texas 77493
    United States

    Site Not Available

  • Research Site

    Kerrville, Texas 78028
    United States

    Terminated

  • Research Site

    Kingwood, Texas 77339
    United States

    Active - Recruiting

  • Research Site

    Lewisville, Texas 75057
    United States

    Suspended

  • Research Site

    McAllen, Texas 78504
    United States

    Active - Recruiting

  • Research Site

    McKinney, Texas 75069
    United States

    Active - Recruiting

  • Research Site

    Paris, Texas 75462
    United States

    Active - Recruiting

  • Research Site

    Plano, Texas 75093
    United States

    Active - Recruiting

  • Research Site

    Victoria, Texas 77901
    United States

    Terminated

  • Research Site

    Waco, Texas 76708
    United States

    Active - Recruiting

  • Research Site

    Wichita Falls, Texas 76308
    United States

    Active - Recruiting

  • Research Site

    Wylie, Texas 75098
    United States

    Active - Recruiting

  • Research Site

    Bountiful, Utah 84010
    United States

    Site Not Available

  • Research Site

    Ogden, Utah 84405
    United States

    Active - Recruiting

  • Research Site

    Salt Lake City, Utah 84107
    United States

    Terminated

  • Research Site

    West Jordan, Utah 84088
    United States

    Terminated

  • Research Site

    West Valley City, Utah 84120
    United States

    Active - Recruiting

  • Research Site

    Newport News, Virginia 23606
    United States

    Active - Recruiting

  • Research Site

    Norfolk, Virginia 23504
    United States

    Active - Recruiting

  • Research Site

    Portsmouth, Virginia 23703
    United States

    Active - Recruiting

  • Research Site

    Richmond, Virginia 23226
    United States

    Active - Recruiting

  • Research Site

    Spokane, Washington 99218
    United States

    Active - Recruiting

  • Research Site

    Morgantown, West Virginia 26505
    United States

    Terminated

  • Research Site

    Cudahy, Wisconsin 53110
    United States

    Active - Recruiting

  • Research Site

    Milwaukee, Wisconsin 53295
    United States

    Active - Recruiting

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