Postoperative Intraperitoneal Pain Management Following Laparoscopic Cholecystectomy

Last updated: January 9, 2025
Sponsor: Future University in Egypt
Overall Status: Completed

Phase

3

Condition

N/A

Treatment

Granisetron 1 Mg/mL Intravenous Solution

Normal saline

Clinical Study ID

NCT06281418
5-24
  • Ages 18-70
  • All Genders

Study Summary

Postoperative pain management is essential and the inability to treat acute pain appropriately in the first 48 postoperative hours represents a risk factor for developing chronic pain. No. study has investigated IP granisetron as an adjuvant to standard care for postoperative pain management in patients undergoing LC.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients who are scheduled to undergo elective LC.

  • Adults (males and/or females) between the ages of 18-70 years old.

Exclusion

Exclusion Criteria:

  • Chronic pain other than cholelithiasis.

  • Patients who received analgesics or sedatives 24 h before scheduled surgery.

  • Severe hepatic (Child Pugh Class B and C) and renal dysfunction (CrCl <30ml/min)

  • Previous allergic response to granisetron.

  • Pregnancy and lactation

  • Patients with communication problems, cognitive dysfunction, or psychologicaldisorders

  • Daily corticosteroid use

Study Design

Total Participants: 46
Treatment Group(s): 2
Primary Treatment: Granisetron 1 Mg/mL Intravenous Solution
Phase: 3
Study Start date:
February 29, 2024
Estimated Completion Date:
December 04, 2024

Study Description

Postoperative pain is a main challenge for delayed hospital discharge in Laparoscopic cholecystectomy. . Postoperative pain management is essential and the inability to treat acute pain appropriately in the first 48 postoperative hours represents a risk factor for developing chronic pain. Granisetron is frequently used as a premedication to avoid postoperative nausea and vomiting in patients who have undergone general anesthesia. The purpose of this study is evaluating the efficacy and tolerability of IP granisetron on postoperative pain control in patients undergoing LC

Connect with a study center

  • National Hepatology and Tropical Research Institute

    Cairo, 11617
    Egypt

    Site Not Available

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