Adrenal Project: Clinical and Epidemiological Characterization of Adrenocortical Carcinoma in a Brazilian Cohort

Last updated: February 10, 2025
Sponsor: Latin American Cooperative Oncology Group
Overall Status: Active - Recruiting

Phase

N/A

Condition

Adrenal Cancer

Carcinoma

Treatment

N/A

Clinical Study ID

NCT06279442
LACOG 0723
  • Ages > 18
  • All Genders

Study Summary

This is a retrospective observational cohort study. The clinical, pathological and treatment data of participants identified with adrenocortical carcinoma from the year 2000 onwards will be evaluated. Participants recruited for this study will be identified at the participating sites.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Participants over 18 years old;

  • Diagnosis of adrenocortical carcinoma with at least one clinical evaluation at thereference institution;

  • Initial diagnosis or recurrence from the year 2000 onwards.

Exclusion

Exclusion Criteria:

  • Participants with insufficient clinical or pathological data in the medical records.

Study Design

Total Participants: 150
Study Start date:
October 09, 2024
Estimated Completion Date:
August 25, 2025

Study Description

Adrenocortical carcinoma is one of the rarest neoplasms in the world. In Brazil, especially in the South and Southeast regions, the incidence of adrenocortical tumors is around 15 times higher than in the rest of the world, largely attributed to the significant prevalence of the TP53-R337H germline mutation in this population. In view of this characteristic, the clinical and epidemiological characterization of this cohort, as well as the identification of prognostic factors, is of great importance. The starting point for this project was the cohort of 66 participants with adrenal carcinoma included in the final project of the medical residency in clinical oncology at the A.C. Camargo Cancer Center by student Rafael Haikal dos Santos Abduch. The aim is to include case studies from the main Brazilian site that have followed up and treated patients with adrenal carcinoma.

Connect with a study center

  • Pronutrir - Suporte Nutricional e Quimioterapia

    Fortaleza, Ceará 60.810-180
    Brazil

    Active - Recruiting

  • Hospital do Câncer do Maranhão Dr. Tarquínio Lopes Filho

    São Luis, Maranhão 65.015-460
    Brazil

    Active - Recruiting

  • Hospital Erasto Gaertner

    Curitiba, Paraná 81.520-060
    Brazil

    Active - Recruiting

  • Hospital Santa Joana Recife (Instituto Américas PE)

    Recife, Pernambuco 52.011-000
    Brazil

    Active - Recruiting

  • UOPECCAN - Hospital do Câncer de Cascavel

    Cascavel, Santa Catarina 85.806-300
    Brazil

    Active - Recruiting

  • FUNFARME - Hospital de Base de São José do Rio Preto

    São José do Rio Preto, São Paulo 15.090-000
    Brazil

    Active - Recruiting

  • INCA - Instituto Nacional de Câncer

    Rio de Janeiro, 20.230-130
    Brazil

    Active - Recruiting

  • A.C. Camargo Cancer Center

    São Paulo, 01.509-001
    Brazil

    Active - Recruiting

  • BP - A Beneficência Portuguesa de São Paulo

    São Paulo, 01.323-030
    Brazil

    Active - Recruiting

  • HAOC - Hospital Alemão Oswaldo Cruz

    São Paulo, 01.327-001
    Brazil

    Active - Recruiting

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