A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Ulcerative Colitis

Inclusion Criteria:

1. Male or female aged 18-75 years old with diagnosis of UC for at least 30 days. InSouth Korea, the age requirement for adult participants is ≥19 years of age.

2. Confirmed diagnosis of moderately to severely active UC assessed by mMS and ES.

3. Participants with a history of inadequate response to, loss of response to, orintolerance to one or more of conventional, biologic or advance therapies for UC.

4. Participants must meet the contraception recommendations.

Exclusion Criteria:

1. Participants with indeterminate/unclassified inflammatory bowel disease (IBD),microscopic colitis, ischemic colitis, infectious colitis, radiation colitis,diverticular disease associated with colitis, and/or clinical/histologic findingssuggestive of Crohn's disease (CD).

2. Participants with complications of UC such as strictures, stenoses, fistulas, shortgut syndrome, or any other manifestation that might require surgery during thestudy.

3. Participants with a current ileostomy or colostomy. Participants who had a J-pouchare excluded, as a J-pouch could result in a stoma.

4. Participants who have failed 3 or more classes of advanced therapies.