Extraperitoneal SINgle-port rObotic-assisted Radical Prostatectomy (RARP) Versus Transperitoneal Multi-port RARP in the Treatment Of Prostate Cancer (SINO-TOP)

Inclusion Criteria:

1. Men aged 18 years ≤ age ≤ 75 years;

2. Prostate biopsy within 6 months with diagnosis of organ-localized prostate cancerwith preoperative staging of T1c to T2b,N0M0;.

3. Gleason Score<8.

4. PSA<20ng/ml.

5. Pathologic diagnosis of prostate follicular adenocarcinoma or prostate ductaladenocarcinoma;

6. The patient has healthy sexual function before surgery and intention for sexualactivities after surgery;

7. Physiological condition acceptable for laparoscopic surgery;

8. Willing to cooperate and complete the study follow-up and related examinations;

9. The subject or his agent voluntarily participates in this trial and signs thewritten informed consent;

10. The questionnaire can be completed in Chinese.

11. The patient has been informed of the trial;

Exclusion Criteria:

1. High-risk and non-organ localized prostate cancer (clinical stage ≥ T2c, GS ≥ 8, PSA > 20ng/ml);

2. Special type of prostate cancer， such as neuroendocrine etc.;

3. History of previous abdominal surgery and radiotherapy which may affect abdominalincision and Port placement;

4. Recent surgery of rectum, perianal abscess or around fistula and perineal area;

5. Patients who have undergone previous electro-prostatectomy/enucleation of theprostate;

6. Non-recurrent patients with less than 12 months of follow-up;

7. ECOG>1.

8. Combination of other systemic tumors;

9. had received any type of preoperative antitumor therapy;

10. Suffering from poor general condition with the presence of one of the followingconditions: including severe mental disorders, cardiovascular disease, activeinfections, bone marrow transplantation within 3 months, or significantabnormalities in organ function;

11. Participation in other clinical studies or previous treatment with any gene therapyproduct within the last 3 months;

12. Other conditions that the researchers believe may affect the experimental results orare unethical;