OnabotulinumtoxinA for Trigeminal Neuralgia

Inclusion Criteria:

Men and women age 18 or older

• Judged to be of legal competence

• Sufficient knowledge of written and spoken English

• Capable of attending regular in-person visits

• Have failed/not a candidate/do not want surgery

• Inadequate response to medication - at least 2 trials

• Meeting ICHD criteria for Classical Trigeminal Neuralgia 13.1.1.1

• Patients with frequency > 10 attacks per week

• Stable dose of medications in the last 2 weeks

Exclusion Criteria:

• Secondary or Idiopathic TN, or Painful Trigeminal Neuropathy as defined by the ICHD (13.1.1.2, 13.1.1.3, 13.1.2)

• Pregnant or breast feeding (while it is rare that a patient will be pregnant withTN, there is not sufficient data to say definitively that onabotA is ok to useduring pregnancy and nursing, it is still rated Class C)

• Neuromuscular disease

• On aminoglyocosides

• Not currently enrolled in any other studies