Safety and Efficacy Study of OMS906 in Patients With C3G and ICGN

Inclusion Criteria:

1. Male or female adults 18 years and older.
2. Competent to provide informed consent and has completed informed consent procedures.
3. Diagnosis of C3G, including dense deposit disease, or ICGN confirmed by biopsy within 36 months of screening.
4. Two 24-hour UPCR ≥ 0.8 gm/gm with the 2 collections separated by 14 - 28 days.
5. GFR estimated by the CKD-EPI equation ≥ 45 mL/min/1.73 m2.
6. Serum C3 concentration less than the lower limit of laboratory normal duringscreening.
7. Must be on stable maximally tolerated or allowed dose of ACE inhibitor or ARB for atleast 90 days.
8. If receiving a sodium-glucose co-transporter-2 (SGLT-2) inhibitor, must be on a stabledose for at least 90 days.
9. If receiving mycophenolate mofetil, a mineralocorticoid receptor antagonist, or acorticosteroid, must be on stable dose for at least 90 days.
10. Have current vaccination status for Neisseria meningitidis, Streptococcus pneumoniaand Haemophilus influenza (where available) and agree to maintain vaccinationthroughout the study. Patients who have not received these vaccinations at the time of screening may bevaccinated at any time prior to 2 weeks before the first study drug administration.Vaccine serotypes will be chosen by the local standard of care and serotypeprevalence.
11. Female patients of child-bearing potential must have a negative highly sensitivepregnancy test at screening and prior to each dose of OMS906.
12. Females must use highly effective birth control* to prevent pregnancy during theclinical trial and for 20 weeks (140 days) following their last dose of study drug.
13. Males must use highly effective birth control* with a female partner to preventpregnancy during the clinical trial and for 20 weeks (140 days) following their lastdose of study drug.

Exclusion Criteria:

1. History of major organ transplant or hematopoietic stem cell/marrow transplant.
2. Have known congenital deficiency of any of complement factors C1q, C1r, C1s, C2 or C4.
3. Have rapidly progressing glomerulonephritis defined as a 50% or greater decline in theeGFR within 3 months with renal biopsy findings of glomerular crescent formation seenin at least 50% of glomeruli.
4. Have renal biopsy findings showing interstitial fibrosis/tubular atrophy of more than 50%.
5. Immunodeficiency or treatment with immunosuppressive agents (except mycophenolatemofetil or corticosteroids at the prednisone equivalent of ≤ 7.5 mg/day in patientswith C3G only) within 90 days of screening.
6. Treatment with rituximab within 6 months of screening.
7. Resting blood pressure > 140/90 mmHg during screening.
8. History of any active malignancy within 5 years of screening except non-melanoma skincancers.
9. History of monoclonal gammopathy of unknown significance or any autoimmune disorder.
10. Elevation of liver function tests, defined as total bilirubin > 2 × upper limit ofnormal (ULN), direct bilirubin > 1.5 × ULN, and elevated transaminases, alanineaminotransferase (ALT) or aspartate aminotransferase (AST) > 2 × ULN.
11. History of any severe hypersensitivity reactions to other monoclonal antibodies orexcipients included in the OMS906 preparation.
12. Significant active bacterial or viral infection within the 2 weeks prior to screeningincluding Covid-19 infection.
13. Use of any other complement inhibitor within 6 months prior to the screening visit.
14. Have human immunodeficiency virus, hepatitis B, or untreated hepatitis C infection.
15. Pregnant, planning to become pregnant, or nursing female patient.
16. Recent surgery requiring general anesthesia within the 2 weeks prior to screening orexpected to have surgery requiring general anesthesia during the treatment period.
17. History of any significant medical, neurologic, or psychiatric disorder that in theopinion of the investigator would make the patient unsuitable for participation in thestudy.
18. Treatment with any investigational medicinal product or investigational device within 30 days (or within 5 × its half-life in days, whichever is the longer period) prior toscreening, or participation in another concurrent clinical trial involving atherapeutic intervention. Participation in observational and/or registry studies ispermitted.
19. Unable or unwilling to comply with the requirements of the study.