Middle Meningeal Artery Embolization (MMAE) Outcomes for Chronic Subdural Hematoma (cSDH)

Last updated: January 5, 2026
Sponsor: Montefiore Medical Center
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT06181994
2023-15327
  • Ages > 18
  • All Genders

Study Summary

This multi-center retrospective cohort study aims to investigate the real-world outcomes of chronic subdural hematoma treated with MMAE, including clinical effectiveness, recurrence rates, and safety profile.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Consecutive adult patients (18 yrs. of age or older)

  • Endovascular embolization of middle meningeal artery using any embolizationmaterial:

PVA particles; Onyx, nBCA glue; dimethyl sulfoxide, microcoils, PVA with microcoils

Exclusion

Exclusion Criteria:

  • Endovascular embolization of middle meningeal artery using any other embolizationmaterial

Study Design

Total Participants: 5000
Study Start date:
December 05, 2023
Estimated Completion Date:
August 31, 2026

Study Description

Chronic subdural hematoma (cSDH) is a prevalent neurosurgical condition marked by the accumulation of blood in the subarachnoid space. Primarily affecting elderly individuals, cSDH is associated with significant morbidity and mortality rates. Current standard treatments for cSDH involve surgical evacuation through burr hole craniotomy or twist-drill craniotomy; however, recent research has illuminated the potential significance of the middle meningeal artery (MMA) in cSDH pathogenesis, suggesting an innovative minimally invasive treatment avenue. The investigator team is attempting to determine whether MMA embolization has demonstrated a favorable safety profile with a low incidence of treatment-related complications.

Connect with a study center

  • Austin Health

    Heidelberg 2163654, Victoria 2145234 3084
    Australia

    Active - Recruiting

  • Toronto Western Hospital

    Toronto 6167865, Ontario 6093943 M5T 2S8
    Canada

    Completed

  • Unity Health Toronto

    Toronto 6167865, Ontario 6093943 M5C 2T2
    Canada

    Completed

  • University of Toronto

    Toronto 6167865, Ontario 6093943 M5S 1A1
    Canada

    Active - Recruiting

  • Baptist Health South Florida, Inc.

    Coral Gables 4151871, Florida 4155751 33143
    United States

    Active - Recruiting

  • Mayo Clinic Florida

    Jacksonville 4160021, Florida 4155751 32224
    United States

    Completed

  • Orlando Regional Medical Center

    Orlando 4167147, Florida 4155751 32806
    United States

    Active - Recruiting

  • University of Chicago Medicine

    Chicago 4887398, Illinois 4896861 60637
    United States

    Active - Recruiting

  • University of Illinois Chicago

    Chicago 4887398, Illinois 4896861 60607
    United States

    Completed

  • The University of Iowa

    Iowa City 4862034, Iowa 4862182 52242
    United States

    Completed

  • Beth Israel Deaconess Medical Center (BIDMC)/Harvard Medical School

    Boston 4930956, Massachusetts 6254926 02215
    United States

    Active - Recruiting

  • Massachusetts General Hospital

    Boston 4930956, Massachusetts 6254926 02114
    United States

    Active - Recruiting

  • Lahey Hospital and Medical Center

    Burlington 4931737, Massachusetts 6254926 01805
    United States

    Active - Recruiting

  • Mayo Clinic

    Rochester 5043473, Minnesota 5037779 55905
    United States

    Completed

  • Montefiore Medical Center

    Bronx, New York 10467
    United States

    Site Not Available

  • Montefiore Medical Center

    The Bronx 5110266, New York 5128638 10467
    United States

    Active - Recruiting

  • Geisinger Health

    Danville 5186327, Pennsylvania 6254927 17822
    United States

    Completed

  • Thomas Jefferson University

    Philadelphia 4560349, Pennsylvania 6254927 19144
    United States

    Active - Recruiting

  • UTHealth Houston

    Houston 4699066, Texas 4736286 77030
    United States

    Completed

  • HCA Houston Healthcare Kingwood

    Kingwood 7534469, Texas 4736286 77339
    United States

    Completed

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