Influenza & COVID-19 Obstetric and Perinatal Epidemiology Study in India

Inclusion Criteria:

Women aged 18 to 50 years registering for antenatal care (ANC) at Government Medical College Hospital (GMC) Nagpur, India

• Estimated Gestational Age at registration <14 weeks based on ultrasound report atthe baseline study visit;

• Intends to receive pregnancy, labor and delivery and neonatal care at GMC;

• Plans to live within the city limits of Nagpur throughout their pregnancy and laborand delivery to facilitate access to GMC for evaluation of ILI and COVID-19symptoms;

• Willing to be contacted two times per week by call or text for ILI/ COVID-19 symptomscreening and return to GMC for evaluation and an NP swab/evaluation if symptoms arereported;

• Willing to take temperature with the provided digital thermometer, and maintain asymptom diary after training;

• Willing to provide information on pregnancy and neonatal outcomes if care occursoutside GMC;

• Willing to permit venous blood draws on at least 4 timepoints --1) Baseline studyvisit, 2)28-34 weeks, 3) 37 weeks - prior to delivery and 4) after delivery;

• Willing to permit blood draws if hospitalized at GMC for COVID-19 infection;

• Willing to consent to participate in the study

Exclusion Criteria:

• Anyone who is deemed to have limited decision-making capacity as defined by BostonUniversity IRB i.e. Substantial impairment of cognitive functions (e.g. attention,comprehension, memory, and intellect), or conditions that might affect theircognitive functions.

• Anyone who is deemed to have limited capacity to consent as defined by BostonUniversity Institutional Review Board (IRB) i.e. The ability to provide legallyeffective consent to enroll in a research study (AAHRPP definition).