Periodontal Regeneration With Recombinant Human Platelet Derived Growth Factor (rH-PDGF-BB) and Allograft

Last updated: April 29, 2024
Sponsor: Universidad Autonoma de Nuevo Leon
Overall Status: Active - Recruiting

Phase

2

Condition

N/A

Treatment

Allograft and Saline solution

Allograft and rHPDGF-BB

Clinical Study ID

NCT06162832
SPSI-010613
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Growth factors are defined as small proteins that trigger a cellular response after binding to cell receptors; Tissue engineering is now clinically applicable in a commercially available system involving the use of recombinant human platelet-derived growth factor.

The objective of this study is to evaluate clinical and radiographic parameters in bone defects treated with platelet-derived growth factor in combination with allograft.

Our hypothesis: Defects treated with DFDBA and rhPDGF-BB have better clinically and radiographic results that the defects treated with DFDBA and saline solution.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Clinical diagnosis of periodontitis
  • Infrabony defects of 2 walls, 3 walls and combined defects
  • Patients ASA (American Society of Anesthesiologists) I and II
  • Patients who smoke less than 10 cigarettes

Exclusion

Exclusion Criteria:

  • Patients undergoing bisphosphonate therapy
  • Furcation defects
  • Patients with evidence of blood dyscrasias.
  • Pregnant patient

Study Design

Total Participants: 30
Treatment Group(s): 2
Primary Treatment: Allograft and Saline solution
Phase: 2
Study Start date:
January 10, 2024
Estimated Completion Date:
January 15, 2025

Study Description

The study will be performed in 30 periodontal defects of 2 and 3 walls. The experimental group will consist of DFDBA placement with rhPDGF-BB and control DFDBA with saline solution. The clinical parameters recorded were Probing deep (PD), clinical attachment level (CAL), recession depth, Index of bleeding and plaque at baseline and at six months. Our universe is patients with periodontitis attending at the clinical in Periodontics at the Autonomous University of Nuevo Leon (UANL) School of Dentistry.

Connect with a study center

  • Posgrado de Periodoncia, Facultad de Odontología, Universidad Autónoma de Nuevo León

    Monterrey, Nuevo León 64460
    Mexico

    Active - Recruiting

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