A Trial to Learn if the Combination of Fianlimab, Cemiplimab, and Chemotherapy is Safe and Works Better Than the Combination of Cemiplimab and Chemotherapy in Adult Patients With Non-Small Cell Lung Cancer That Can be Treated With Surgery

Key Inclusion Criteria:

1. Patients with newly diagnosed, histologically confirmed, fully resectable stage IIto IIIB (N2) NSCLC as per American Joint Committee on Cancer (AJCC) version 8

2. For patients with evidence of mediastinal adenopathy on imaging, mediastinal lymphnode sampling is required as defined in the protocol

3. All patients must have disease status showing no evidence of distant metastasesdocumented by a complete physical examination and imaging studies performed within 4weeks prior to randomization as defined in the protocol

4. A patient must have an evaluable Programmed cell death ligand-1 (PD-L1)immunohistochemistry (IHC) result as defined in the protocol

5. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

6. Adequate bone marrow, hepatic and kidney function as defined in the protocol

Key Exclusion Criteria:

1. Any evidence of locally advanced unresectable or metastatic disease as defined inthe protocol

2. Patients with tumors with known Epidermal growth factor receptor (EGFR) genemutations, anaplastic lymphoma kinase (ALK) gene translocations as defined in theprotocol

3. Uncontrolled infection with human immunodeficiency virus (HIV), hepatitis B (HBV) orhepatitis C virus (HCV) infection as defined in the protocol

4. Treatment with anti-cancer therapy including immunotherapy, chemotherapy,radiotherapy, or biological therapy in the 3 years prior to randomization. Adjuvanthormonotherapy used for breast cancer or other hormone-sensitive cancers in longterm remission is allowed.

5. Patients with a history of myocarditis

Note: Other protocol-defined Inclusion/ Exclusion Criteria apply