Association of Dysbiosis and Immune Response in Bronchiolitis in Under 12 Months -Old Infants

Last updated: February 24, 2025
Sponsor: Assistance Publique - Hôpitaux de Paris
Overall Status: Active - Recruiting

Phase

N/A

Condition

Respiratory Syncytial Virus (Rsv) Infection

Bronchitis (Pediatric)

Treatment

Sampling

Clinical Study ID

NCT06161285
APHP231177
2023-A01688-37
  • Ages 1-12
  • All Genders

Study Summary

Acute bronchiolitis is a common disease in children under the age of two, caused mainly by the respiratory syncytial virus (RSV). Furthermore, given the same medical history, it is still very difficult to predict the course and severity of the infection at the onset of symptoms, Some studies have highlighted the importance of the microbiota (intestinal, oral or nasopharyngeal) and of the immune response to RSV in children, We will include 80 children under 2 years old with hospitalized bronchiolitis and non-hospitalized bronchiolitis. Oral, nasal and stool samples will be taken to study the various microbiota in search of dysbiosis. A capillary blood sample will be taken for immune studies.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Infants <12 months

  • With bronchiolitis during RSV epidemic season

  • No chronic illness

  • No bronchiolitis medical history

  • Signed consent from parents or legal guardians

Exclusion

Exclusion Criteria:

  • Chronic respiratory illness

  • Medical history of bronchiolitis or newborn asthma

  • Treatment with immunosuppressants

  • Patient with no social security affiliation

Study Design

Total Participants: 120
Treatment Group(s): 1
Primary Treatment: Sampling
Phase:
Study Start date:
December 06, 2024
Estimated Completion Date:
April 30, 2026

Connect with a study center

  • APHP, Antoine Béclère Hospital

    Clamart, 92140
    France

    Active - Recruiting

  • AP-HP,Raymond Poincaré Hospital

    Garches, 92380
    France

    Active - Recruiting

  • Réanimation médico-chirurgicale Necker

    Paris, 750
    France

    Active - Recruiting

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