A Study to Evaluate Adverse Events and How Single Ascending Doses of ABBV-141 Move Through the Body of Healthy Adult Western and Asian Participants

Inclusion Criteria:

• A condition of general good health, based upon the results of a medical history,physical examination, vital signs, laboratory profile and a 12-leadelectrocardiogram (ECG).

• Body Mass Index (BMI) is ≥ 18.0 to ≤ 32.0 kg/m2 after rounding to the tenthsdecimal.

For Part 2 only:

-Han Chinese ethnicity or Japanese ethnicity based on the following criteria:

• Han Chinese: First-generation Han Chinese with both parents of Han Chinese descent.

• Japanese: First- or second-generation Japanese with both parents and all fourgrandparents born in Japan and of Japanese descent.

Exclusion Criteria:

• History of epilepsy, any clinically significant cardiac, respiratory (except mildasthma as a child), renal, hepatic, gastrointestinal, hematologic, or psychiatricdisease or disorder, or any uncontrolled medical illness.

• History of any clinically significant sensitivity or allergy to any medication,topical creams, or food.

Additionally for Part 1, only:

• Presence of foreign bodies, local irritation or infections, active skin diseases,tattoos, and/or scars on the thighs which may preclude the skin biopsy collectionsite planned as per schedule of activities.

• History of bruising easily, bleeding disorders, thrombocytopenia, orhypo-coagulation disorder.

• History of sensitivity to or allergies to adhesives or evidence of fragile or easilydamaged skin.

• Evidence of hypertrophic scarring.