Basal Instincts: Towards Better Understanding of Basal Cell Function in Chronic Rhinosinusitis With Nasal Polyps

Last updated: March 21, 2024
Sponsor: Universitaire Ziekenhuizen KU Leuven
Overall Status: Active - Recruiting

Phase

N/A

Condition

Acute Rhinitis

Nasal Obstruction

Allergy (Pediatric)

Treatment

Conchotomy, aesthetic nose surgery or functional endoscopic sinus operation

Clinical Study ID

NCT06129552
S67788
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

During this project, the investigators want to explore in vitro changes in basal cells and the crosstalk with residing immune cells as potential pathogenic mechanisms in CRSwNP vs healthy controls by using surgically resected patient samples.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients over the age of 18
  • Males and females

Exclusion

Exclusion Criteria:

  • CRSwNP
  • AR
  • Smoker, or < 1-year ex-smoker
  • Underlying systematic pathology (Morbus Wegener or Churg Strauss Syndrome for example)

Study Design

Total Participants: 300
Treatment Group(s): 1
Primary Treatment: Conchotomy, aesthetic nose surgery or functional endoscopic sinus operation
Phase:
Study Start date:
December 19, 2023
Estimated Completion Date:
December 31, 2027

Study Description

The investigators want to use patient and healthy control samples to study/compare the following aspects in vitro:

  1. Investigate differences in epithelial and basal cell functions and differentiation characteristics.

  2. Characterize the differences in epithelial cell populations and gene expression patterns. Also include an AR subset, to see if changes are specific for CRSwNP or more general for type 2 inflammatory disease of the upper airways.

  3. Investigate basal cell activation via different environmental triggers through TLR stimulation.

  4. Look at the genetic imprinting of basal cells before and after being exposed to specific triggers.

  5. Investigate whether the secreted proteins from basal cells are chemotactic for other cell populations.

  6. Investigate the interaction between basal and regulatory T cells.

Connect with a study center

  • Peter Hellings

    Leuven, 3000
    Belgium

    Active - Recruiting

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