Prediction of UA/SOD Ratio as a Biomarker of Oxidative Stress in Atrial Fibrillation

Last updated: November 1, 2023
Sponsor: Yinglong Hou
Overall Status: Active - Recruiting

Phase

N/A

Condition

Dysrhythmia

Chest Pain

Gout (Hyperuricemia)

Treatment

atrial fibrillation

Clinical Study ID

NCT06119802
YXLL-KY-2023(044)
  • Ages 18-90
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

To clarify the predictive effects of uric acid and superoxide dismutase as biomarkers of oxidative stress on atrial fibrillation, and to provide greater value for the diagnosis and prediction of atrial fibrillation. It provides a new idea for the prevention and treatment of atrial fibrillation.

Eligibility Criteria

Inclusion

Inclusion Criteria: This retrospective study enrolled all hospitalized patients fromJanuary 2018 to December 2020 at the Department of Cardiology in The First AffiliatedHospital of Shandong First Medical University. The diagnosis of AF was based on 12-leadelectrocardiography (ECG) or 24-hour Holter monitoring, and classification was based on thepublished 2020 ESC guidelines for the diagnosis and management of AF.

Exclusion

Exclusion Criteria:

  1. acute heart failure and acute myocardial infarction;
  2. severe liver or kidney dysfunction (with aspartate aminotransferase or alanineaminotransferase levels three times higher than normal and estimated glomerularfiltration rate <30 ml/ (min*1.73 m2));
  3. malignant tumors;
  4. missing data of laboratory indicators at baseline.

Study Design

Total Participants: 10000
Treatment Group(s): 1
Primary Treatment: atrial fibrillation
Phase:
Study Start date:
January 01, 2022
Estimated Completion Date:
April 30, 2024

Study Description

In recent years, a growing number of reports have shown the importance of oxidative stress in the pathophysiological mechanism of AF. During oxidative stress, there is an imbalance between the production of pro-oxidant reactive species and the antioxidant defenses of the cell, and excessive oxidation leads to oxidative damage and cell death. Redox processes can lead to atrial fibrosis and cardiac remodeling , suggesting that strategies to address myocardial oxidative stress may constitute a reasonable approach for the treatment of AF. However, few studies have reported the relationship between comprehensive oxidative stress-related biomarkers and AF. The purpose of this study was to illuminate the relationship of several blood markers of oxidative stress with AF and to provide new clues for the prevention and treatment of AF.

Connect with a study center

  • Shandong provincal Qianfoshan hospital

    Jinan, Shandong 250014
    China

    Active - Recruiting

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