Effect of Exercise on Appetite in Response to Meals

Last updated: January 4, 2026
Sponsor: University of Glasgow
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Bouts of Exercise

Clinical Study ID

NCT06096233
200220449
  • Ages 18-65
  • Male
  • Accepts Healthy Volunteers

Study Summary

This clinical trial's primary aim is to investigate the acute effect of two exercise bouts (short [10 minutes] and long [30 minutes]) on appetite and appetite-regulatory hormone responses to a standard meal test. The secondary aim is to investigate when the changes in appetite and appetite-regulatory hormones occur during exercise. As an exploratory aim, the researchers will test if the two exercise bouts influence ad libitum energy intake in the periods after the standard meal test. The researchers will compare three groups (control, short exercise, and prolonged exercise) to see if the exercise bouts affect appetite, appetite-regulatory hormones, and energy intake in healthy men.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Males aged 18 years or older.

  • Have stable body mass for at least six months (within ±2 kg).

Exclusion

Exclusion Criteria:

  • Females

  • People who are younger than 18 or older than 65 years old.

  • Have food allergies.

  • Have significant contraindications to exercise (e.g., an injury that would inhibitrunning).

  • Smoking.

  • Suffering from metabolic health issues, e.g., history of diabetes, cardiovasculardisease, or eating disorders.

Study Design

Total Participants: 14
Treatment Group(s): 1
Primary Treatment: Bouts of Exercise
Phase:
Study Start date:
November 06, 2023
Estimated Completion Date:
October 05, 2026

Study Description

Study Design

Screening visit Before conducting the main experiments, the participants will attend a screening visit where consent will be obtained, and they will complete questionnaires to assess health, food preferences, and physical activity. The researchers will then measure the participants' height, weight, waist circumference, and body composition.

After the researchers confirm the eligibility criteria, participants will take part in two treadmill tests to establish maximum oxygen uptake test (V̇O2 max) (Broom et al. 2017).

Experimental design After the screening visit, the participants will complete three main experiments (control, short high-intensity exercise, and prolonged high-intensity exercise) in a counter-balanced design. All experiments began at ~0930, following an overnight fast of at least 10 hours. Participants will consume a prescribed meal in the evening before each main experiment. Following this meal, participants are only allowed to drink water until the start of the main experiments.

At the beginning of the exercise conditions, participants will run on the treadmill for 10 minutes (short) or 30 minutes (prolonged) at a speed estimated to elicit a 75% V̇O2 peak, followed by rest in the laboratory. In the control condition, the researchers will follow the same protocols except that the participants will not perform any exercise. The participants will have a standardized meal after exercise and then an ad libitum buffet meal afterward.

During each experiment, the researchers will assess appetite ratings using 100 mm visual analog scales (Flint et al. 2000). The researchers will also collect blood samples to examine ghrelin, peptide YY, glucagon-like peptide 1, and possibly other blood-borne measures.

Connect with a study center

  • New Lister Building at Glasgow Royal Infirmary

    Glasgow, G31 2ER
    United Kingdom

    Site Not Available

  • New Lister Building at Glasgow Royal Infirmary

    Glasgow 2648579, G31 2ER
    United Kingdom

    Active - Recruiting

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