The Effect of Sequential Feeding for Circadian Rhythm and Gut Flora Rhythm in Critically Ill Patients

Last updated: October 15, 2023
Sponsor: Qingdao University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Sleep Disorders

Treatment

feeding type

Clinical Study ID

NCT06083831
QYFYEC2023-108
  • Ages > 18
  • All Genders

Study Summary

Circadian rhythms plays an important role for healthy. And critical illness contributes to the disruption of circadian rhythms. Not only right but also feeding can affect the circadian clock gene expression. In a investigators' previous study, some metabolic indicators (the albumin level, total cholesterol level and total bile acid level) and the increases in lymphocyte counts in the sequential feeding group were different from those in the continuous feeding group. Investigators think sequential feeding may adjust circadian clock gene expression for its effect on metabolism and immunity. Moreover, sequential feeding did alter the abundances of some gut microbes to some degree in the investigators' previous study. Investigators think sequential feeding may adjust gut flora rhythms.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients newly admitted to ICU were eligible for inclusion.

Exclusion

Exclusion Criteria:

  • An estimated feeding time of less than 10 days in ICU;
  • Diabetes;
  • Gastrointestinal disease (gastrointestinal surgery, gastrointestinal bleeding,pancreatitis, Crohn's disease, ulcerative colitis, irritable bowel syndrome);
  • Inability to tolerate ≥80% of the nutrition target calories (25-30 kcal/kg/d) withenteral feeding through gastric tube;
  • The ability to eat orally at admission.

Study Design

Total Participants: 20
Treatment Group(s): 1
Primary Treatment: feeding type
Phase:
Study Start date:
October 07, 2023
Estimated Completion Date:
May 01, 2024

Connect with a study center

  • The affiliated hospital of qingdao university

    Qingdao, Shan Dong Province 266000
    China

    Active - Recruiting

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