A 104-Week Study of Ritlecitinib Oral Capsules in Adults With Nonsegmental Vitiligo (Active and Stable) Tranquillo 2

Last updated: December 2, 2024
Sponsor: Pfizer
Overall Status: Active - Recruiting

Phase

3

Condition

Vitiligo

Treatment

Ritlecitinib

Placebo

Clinical Study ID

NCT06072183
B7981080
2022-502518-98-00
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to learn about the safety and effects of the study medicine ritlecitinib for the possible treatment of nonsegmental vitiligo. Vitiligo causes white patches on your skin when the cells that give your skin color are destroyed. Nonsegmental means that it can affect both sides of the body such as both knees and both hands.

Ritlecitinib has been tested in earlier clinical studies and has a favorable safety profile. At present there are no approved medications taken by mouth to treat nonsegmental vitiligo.

This study is seeking participants who:

  • Are 18 years of age or older.

  • are confirmed to have nonsegmental vitiligo for at least 3 months.

  • Are willing to stop all other treatments that they may be taking for vitiligo.

In this study participants will be chosen by chance, like drawing names out of a hat to receive 1 of 3 treatments:

•Part I where two different amounts of ritlecitinib (50 mg and 100 mg) are taken once daily. It will be compared to placebo. Placebo is a dummy capsule. It doesn't have any medicine used in the study.

Participants receiving placebo who have not responded to treatment after 52 weeks will be given 100 milligrams or 50 milligrams of ritlecitinib for the remaining 52 weeks of the study.

• In Part II, participants will only receive 100 milligrams of ritlecitinib. About 1000 participants will take part in Part I and around 450 in Part II globally. The study will compare the experiences of people receiving ritlecitinib to those of the people who do not. This will help see if ritlecitinib is safe and effective.

People in Part I will be in this study for about 26 months and people in Part II will be in this study for about 14 months. During the study, participants in part I will need to visit the study site at least 17 times. In part II, participants will visit at least 11 times.

Participants will undergo various tests and procedures such as:

  • vitiligo rating,

  • physical examinations,

  • hearing tests,

  • blood tests,

  • x-ray,

  • ECG,

  • photographs of areas with vitiligo. Participants will be asked to complete questionnaires about their vitiligo.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Participants aged 18 years (or the minimum age of consent in accordance with localregulations) or older (no upper age limit) at Screening.

• Meeting reproductive criteria for female participants. Disease Characteristics:

  1. Eligible participants must have at both Screening and BL:

  • A clinical diagnosis of nonsegmental vitiligo for at least 3 months; and

  • BSA involvement 4% to 60% inclusive, excluding involvements at palms of thehands, soles of the feet, or dorsal aspect of the feet and

  • BSA ≥0.5% involvement on the face. Face is defined as including the area on theforehead to the original hairline, on the cheek to the jawline vertically tothe jawline and laterally from the corner of the mouth to the tragus. Face willnot include scalp, ears, neck, or surface area of the lips, but will includethe nose and the eyelids; and

  • F-VASI ≥0.5 and T-VASI ≥3; and

  • Either active or stable nonsegmental vitiligo at Screening and BL visits. Allparticipants who do not have the features of active vitiligo (defined below)will be classified as having stable disease. Active vitiligo is defined as: Participants will be classified as having active vitiligo based on the presence ofat least one active lesion at BL defined as one of the following:

  • New/extending lesions(s) in the 3 months prior to Screening visit (confirmed byphotographs or medical record);

  • Confetti-like lesion(s); Confetti-like depigmentation is characterized by thepresence of numerous 1-mm to 5-mm depigmented macules in clusters;

  • Trichrome lesion(s); Trichrome lesions have a hypopigmented zone of varyingwidth between normal and completely depigmented skin, resulting in 3 differenthues of skin;

  • Koebner phenomenon/phenomena (excluding Type 1 [history based on isomorphicreaction]). The Koebner phenomenon manifests as depigmentation at sites oftrauma, usually in a linear arrangement. Stable vitiligo is defined as:

• Participants will be classified as having stable vitiligo based on an absence ofsigns of active disease. All participants who do not have the features of activevitiligo (defined above) will be classified as having stable disease. Eligibility is determined at Screening and Baseline based on the resulting scoresfrom the local in-person reads of F-VASI, T-VASI, and BSA.

  1. Additional inclusion criteria are:

  • If receiving concomitant medications for any reason other than vitiligo,participant must be on a stable regimen, which is defined as not starting a newdrug or changing dosage within 7 days or 5 half-lives (whichever is longer)prior to Day 1. Participant must be willing to stay on a stable regimen duringthe duration of the study.

  • Must agree to stop all other treatments for vitiligo from Screening through thefinal follow-up visit.

Exclusion

Exclusion Criteria:

Medical Conditions:

  1. Any medical or psychiatric condition including recent (within the past year) oractive suicidal ideation/behavior or laboratory abnormality that may increase therisk of study participation or, in the investigator's judgment, make the participantinappropriate for the study.

• Any psychiatric condition including recent or active suicidal ideation or behaviorthat meets defined criteria.

  1. Medical conditions pertaining to vitiligo and other diseases/conditions affectingthe skin:

  • Participants that have other types of vitiligo that do not meet criteria foractive or stable vitiligo as noted in inclusion criteria (including but notlimited to segmental vitiligo and mixed vitiligo).

  • Currently have active forms of other hypopigmentation (including but notlimited to Vogt-Koyanagi-Harada disease, malignancy-induced hypopigmentation [melanoma and mycosis fungoides], post-inflammatory hypopigmentation,pityriasis alba [minor manifestation of atopic dermatitis], senile leukoderma [age-related depigmentation], chemical/drug-induced leukoderma, ataxiatelangiectasia, tuberous sclerosis, melasma, and congenital hypopigmentationdisorder including piebaldism, Waardenburg syndrome, hypomelanosis of Ito,incontinentia pigmenti, dyschromatosis symmetrica hereditarian, xerodermapigmentosum, and nevus depigmentosus). NOTE: Coexistence of halo nevus/nevi (also known as Sutton nevus/nevi) is permitted.

  • Currently have active forms of inflammatory skin disease(s) or evidence of skinconditions (for example, but not limited to morphea, discoid lupus, leprosy,syphilis, psoriasis, seborrheic dermatitis) at the time of the Screening or BLVisit that in the opinion of the investigator would interfere with evaluationof vitiligo or response to treatment.

  • Leukotrichia in more than 33% of the face surface area affected with vitiligolesions or leukotrichia in more than 33% of the total body surface areaaffected with vitiligo lesions.

  • Have a superficial skin infection within 2 weeks prior to first dose on Day 1.NOTE: participants may be rescreened after the infection resolves.

  1. General Infection History:

  • Have a history of systemic infection requiring hospitalization, parenteralantimicrobial, antiviral (including biologic treatment), antiparasitic,antiprotozoal, or antifungal therapy, or as otherwise judged clinicallysignificant by the investigator within 6 months prior to Day 1.

  • Have active acute or chronic infection requiring treatment with oralantibiotics, antivirals, antiparasitics, antiprotozoals, or antifungals within 4 weeks prior to Day 1. NOTE: participants may be rescreened after theinfection resolves.

  • Evidence or history of untreated, currently treated or inadequately treatedactive or latent infection with Mycobacterium tuberculosis.

  1. Specific Viral Infection History:

  • History (single episode) of disseminated HZ or disseminated herpes simplex orrecurrent (more than one episode of) localized, dermatomal HZ.

  • Infected with HBV or HCV: all participants will undergo screening for HBV andHBC for eligibility.

  • Participants who are positive for HCVAb and HCV RNA will not be eligible forthis study.

  • Have a known immunodeficiency disorder (including positive serology for HIV atscreening) or a first-degree relative with a hereditary immunodeficiency.

  1. Other Medical Conditions:

  • Current or recent history of clinically significant severe, progressive, oruncontrolled renal (including but not limited to active renal disease or recentkidney stones), hepatic, hematological, gastrointestinal, metabolic, endocrine (eg, untreated hypovitaminosis D or hypothyroidism), pulmonary, cardiovascular,psychiatric, immunologic/rheumatologic or neurologic disease; or have any othersevere acute or chronic medical or psychiatric condition or laboratoryabnormality that may increase the risk associated with study participation orinvestigational product administration, or interfere with the interpretation ofstudy results; or in the opinion of the investigator or Pfizer (or designee),the participant is inappropriate for entry into this study, or unwilling/unableto comply with study procedures and lifestyle requirements.

  • History of severe allergic or anaphylactoid reaction to any kinase inhibitor ora known allergy/hypersensitivity to any component (including excipients) of thestudy intervention.

  • Have hearing loss with progression over the previous 5 years, sudden hearingloss, or middle or inner ear disease such as otitis media, cholesteatoma,Meniere's disease, labyrinthitis, or other auditory condition that isconsidered current, fluctuating, or progressive.

  • Have a history of any lymphoproliferative disorder such as EBV-relatedlymphoproliferative disorder, history of lymphoma, history of leukemia, orsigns and symptoms suggestive of current lymphatic or lymphoid disease.

  • Abnormal findings on the Screening chest imaging (eg, chest x-ray). Chestimaging may be performed up to 12 weeks prior to screening. Documentation ofthe official reading must be located and available in the source documentation.

  • Long QT Syndrome, a family history of Long QT Syndrome, or a history of TdP.

  • Have any malignancies or have a history of malignancies with the exception ofadequately treated or excised nonmetastatic basal cell or squamous cell cancerof the skin or cervical carcinoma in situ.

  • Significant trauma or major surgery within 1 month of the first dose of studydrug or considered in imminent need for surgery or with elective surgeryscheduled to occur during the study. Prior/Concomitant Therapy:

  1. Have received any of the prohibited treatment regimens specified. Prior/Concurrent Clinical Study Experience:

  2. Previous administration with an investigational drug or vaccine that do not affectvitiligo within 4 weeks of Day 1 [Baseline] or within 5 half-lives, whichever islonger. Diagnostic Assessments: Any of the following abnormalities in clinical laboratory tests at Screening, asassessed by the study-specific laboratory and, if deemed necessary, confirmed by asingle repeat:

  3. Renal impairment

  4. Hepatic dysfunction

  5. Other laboratory abnormalities

  6. Standard 12-lead ECG that demonstrates clinically relevant abnormalities Other Exclusion Criteria:

  7. Investigator site staff directly involved in the conduct of the study and theirfamily members, site staff otherwise supervised by the investigator, and sponsor andsponsor delegate employees directly involved in the conduct of the study and theirfamily members.

  8. In South Africa only participants are excluded without one of the following:

  • Document evidence form a health professional of having received varicellavaccination (two doses); or

  • Evidence of prior exposure to VZV based on serological testing (ie a positiveVZV IgG Ab result) at Screening.

Study Design

Total Participants: 1450
Treatment Group(s): 2
Primary Treatment: Ritlecitinib
Phase: 3
Study Start date:
November 08, 2023
Estimated Completion Date:
July 14, 2027

Study Description

Study B7981080 is a Phase 3 randomized, double-blind, multicenter study with a 52-week placebo-controlled period (Part Ia) followed by a double-blind 52-week extension period (Part Ib) that includes randomized dose-up/down titration and a de novo 52-week non-randomized open-label cohort (Part II), investigating the efficacy, safety, and tolerability of ritlecitinib 100 mg QD and 50 mg QD compared with placebo in adult participants with nonsegmental active or stable vitiligo

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    Nagoya, Aichi 457-8510
    Japan

    Active - Recruiting

    5,271.12 miles

  • Unlimited Diagnostic Center

    Hialeah, Florida 33016
    United States

    Active - Recruiting

    5,271.41 miles

  • Harmony Medical Research Institute

    Hialeah, Florida 33016
    United States

    Site Not Available

    5,271.41 miles

  • Wellness Clinical Research

    Miami Lakes, Florida 33016
    United States

    Active - Recruiting

    5,271.41 miles

  • Direct Helpers Research Center

    Hialeah, Florida 33012
    United States

    Active - Recruiting

    5,271.79 miles

  • SouthCoast Research Center

    Miami, Florida 33136
    United States

    Active - Recruiting

    5,272.3 miles

  • Clever Medical Research

    Miami, Florida 33126
    United States

    Active - Recruiting

    5,276.34 miles

  • De La Pedraja Radiology Associates

    Coral Gables, Florida 33134
    United States

    Active - Recruiting

    5,276.7 miles

  • Miami Dermatology and Laser Research

    Miami, Florida 33133
    United States

    Active - Recruiting

    5,276.9 miles

  • Miami Dermatology and Laser Institute

    Miami, Florida 33133
    United States

    Site Not Available

    5,276.9 miles

  • Bio-Medical Research LLC

    Miami, Florida 33144
    United States

    Active - Recruiting

    5,277.73 miles

  • Ecco Lab Group Co

    Miami, Florida 33144
    United States

    Active - Recruiting

    5,277.73 miles

  • Gamma Diagnostic Lab

    Doral, Florida 33172
    United States

    Active - Recruiting

    5,278.4 miles

  • South Miami Medical & Research Group

    Miami, Florida 33155
    United States

    Site Not Available

    5,279.14 miles

  • Health and Life Research Institute

    Miami, Florida 33155
    United States

    Active - Recruiting

    5,279.14 miles

  • All Hearing Aid, LLC

    Miami, Florida 33155
    United States

    Active - Recruiting

    5,279.14 miles

  • New Horizon Research Center

    Miami, Florida 33165
    United States

    Active - Recruiting

    5,281.09 miles

  • Sunset Radiology & Women Center

    Miami, Florida 33173
    United States

    Active - Recruiting

    5,282.83 miles

  • Skin Research of South Florida

    Miami, Florida 33173
    United States

    Active - Recruiting

    5,282.83 miles

  • Well Pharma Medical Research, Corp.

    Miami, Florida 33173
    United States

    Active - Recruiting

    5,282.83 miles

  • FXM Clinical Research - Miami

    Miami, Florida 33175
    United States

    Site Not Available

    5,282.92 miles

  • Kendall Audiology & Hearing Aid Center

    Miami, Florida 33176
    United States

    Active - Recruiting

    5,285.22 miles

  • JD Medical Group

    Miami, Florida 33176
    United States

    Active - Recruiting

    5,285.22 miles

  • Sanitas Research

    Miami, Florida 33186
    United States

    Active - Recruiting

    5,287.37 miles

  • National Taiwan University Hospital

    Taipei, 10002
    Taiwan

    Site Not Available

    5,287.4 miles

  • Taipei Veterans General Hospital

    Taipei, 11217
    Taiwan

    Site Not Available

    5,287.4 miles

  • Hamamatsu University Hospital

    Hamamatsu, Shizuoka 431-3192
    Japan

    Active - Recruiting

    5,324.51 miles

  • Tokyo Medical University Ibaraki Medical Center

    Inashiki, Ibaraki 300-0395
    Japan

    Active - Recruiting

    5,334.04 miles

  • Juntendo University Urayasu Hospital

    Urayasu, Chiba 279-0021
    Japan

    Active - Recruiting

    5,338.55 miles

  • Toho University Sakura Medical Center

    Sakura, Chiba 285-8741
    Japan

    Active - Recruiting

    5,344.61 miles

  • Oregon Dermatology and Research Center

    Portland, Oregon 97210
    United States

    Active - Recruiting

    5,346.17 miles

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung,
    Taiwan

    Site Not Available

    5,369.4 miles

  • Velocity Clinical Research at The Dermatology Clinic, Baton Rouge

    Baton Rouge, Louisiana 70808
    United States

    Site Not Available

    5,417.22 miles

  • University of Utah Medical Center

    Salt Lake City, Utah 84112
    United States

    Site Not Available

    5,418.06 miles

  • University of Utah

    Murray, Utah 84107
    United States

    Site Not Available

    5,425.68 miles

  • Springville Dermatology - Springville/CCT Research

    Springville, Utah 84663
    United States

    Site Not Available

    5,444.7 miles

  • Dermatology & Advanced Aesthetics

    Lake Charles, Louisiana 70605
    United States

    Site Not Available

    5,505.72 miles

  • The Woodlands Dermatology Associates, PA

    The Woodlands, Texas 77380
    United States

    Site Not Available

    5,578.99 miles

  • Center for Clinical Studies

    Houston, Texas 77004
    United States

    Active - Recruiting

    5,599.2 miles

  • Global Imaging

    Sugar Land, Texas 77478
    United States

    Active - Recruiting

    5,613.37 miles

  • Complete Dermatology

    Sugar Land, Texas 77479
    United States

    Active - Recruiting

    5,617.36 miles

  • Fort Bend Hearing

    Sugar Land, Texas 77479
    United States

    Active - Recruiting

    5,617.36 miles

  • Austin Institute for Clinical Research

    Pflugerville, Texas 78660
    United States

    Site Not Available

    5,631.0 miles

  • Integrative Skin Science and Research

    Sacramento, California 95815
    United States

    Active - Recruiting

    5,766.63 miles

  • Kaiser Permanente

    Oakland, California 94611
    United States

    Active - Recruiting

    5,831.8 miles

  • Kaiser Permanente

    San Francisco, California 94118
    United States

    Active - Recruiting

    5,840.06 miles

  • Center for Dermatology and Plastic Surgery/CCT Research

    Scottsdale, Arizona 85260
    United States

    Active - Recruiting

    5,859.83 miles

  • L.A. Universal Research Center, Inc.

    Los Angeles, California 90057
    United States

    Site Not Available

    5,987.55 miles

  • Wallace Medical Group, Inc

    Los Angeles, California 90056
    United States

    Active - Recruiting

    5,993.98 miles

  • Wolverine Clinical Trials

    Santa Ana, California 92705
    United States

    Active - Recruiting

    5,996.32 miles

  • Wolverine Clinical Trials

    Tustin, California 92780
    United States

    Active - Recruiting

    5,997.58 miles

  • Cura Clinical Research - Oxnard

    Oxnard, California 93030
    United States

    Active - Recruiting

    5,998.84 miles

  • Mission Dermatology Center

    Rancho Santa Margarita, California 92688
    United States

    Site Not Available

    6,000.28 miles

  • Servicios Hospitalarios de Mexico S.A. DE C.V.

    Chihuahua, 31238
    Mexico

    Site Not Available

    6,001.75 miles

  • First OC Dermatology Research Inc

    Fountain Valley, California 92708
    United States

    Active - Recruiting

    6,002.3 miles

  • Seaside Audiology Vertigo & Ear Specialists

    Huntington Beach, California 92648
    United States

    Active - Recruiting

    6,005.45 miles

  • Peninsula Research Associates

    Rolling Hills Estates, California 90274
    United States

    Active - Recruiting

    6,007.67 miles

  • University of California San Diego - La Jolla

    San Diego, California 92122
    United States

    Active - Recruiting

    6,038.84 miles

  • Arké SMO S.A de C.V

    Veracruz, 91910
    Mexico

    Site Not Available

    6,234.72 miles

  • Clinic EvroDerma

    Sofia, Sofia (stolitsa) 1606
    Bulgaria

    Site Not Available

  • Alpha Recherche Clinique

    Quebec, G2J 0C4
    Canada

    Active - Recruiting

  • Hautzentrum im Jahrhunderthaus

    Bochum, Nordrhein-westfalen 44793
    Germany

    Active - Recruiting

  • Allergo-Derm Bakos Kft

    Szolnok, Jász-nagykun-szolnok 5000
    Hungary

    Site Not Available

  • Presidio Ospedaliero Firenze Centro Piero Palagi

    Florence, Firenze 50125
    Italy

    Active - Recruiting

  • DermoDent Centrum Medyczne Aldona Czajkowska Rafał Czajkowski s.c.

    Osielsko, Kujawsko-pomorskie 86-031
    Poland

    Site Not Available

  • Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica

    Banska Bystrica, Banskobystrický KRAJ 97517
    Slovakia

    Active - Recruiting

  • St George Dermatology & Skin Cancer Centre

    Kogarah, New South Wales 2217
    Australia

    Site Not Available

  • Diagnostic Consultative Centre (DCC) - Foкus 5

    Sofia, Sofia (stolitsa) 1463
    Bulgaria

    Site Not Available

  • Hautarztpraxis Dr. Gerlach

    Dresden, Sachsen 01097
    Germany

    Active - Recruiting

  • Kindai University Nara Hospital

    Ikoma City, Nara 630-0293
    Japan

    Active - Recruiting

  • Clinica Dermatoestetica Prywatny Gabinet Dermatologiczny I Alergologiczny Prof.Dr Hab.Med. Barbara Z

    Bydgoszcz, Kujawsko-pomorskie 85-650
    Poland

    Active - Recruiting

  • Specjalistyczny Gabinet Dermatologiczny Aplikacyjno-Badawczy, Marek Brzewski, Paweł Brzewski spółk

    Kraków, Małopolskie 30-002
    Poland

    Site Not Available

  • Guy's & St Thomas' NHS Foundation Trust

    London, London, CITY OF SE1 9RT
    United Kingdom

    Site Not Available

  • Southampton General Hospital

    Southampton, Hampshire SO16 6YD
    United Kingdom

    Active - Recruiting

  • Veracity Clinical Research

    Woolloongabba, Queensland 4102
    Australia

    Site Not Available

  • UZ Leuven

    Leuven, Vlaams-brabant 3000
    Belgium

    Active - Recruiting

  • West China Hospital, Sichuan University

    Cheng Du, Sichuan 610041
    China

    Active - Recruiting

  • Klinikum Bielefeld gem. GmbH

    Bielefeld, Nordrhein-westfalen 33647
    Germany

    Active - Recruiting

  • Universitätsklinikum Bonn

    Bonn, Nordrhein-westfalen 53127
    Germany

    Site Not Available

  • Radiologie Ulrichshaus

    Magdeburg, Sachsen-anhalt 39104
    Germany

    Active - Recruiting

  • Trials in Medicine

    Mexico City, Distrito Federal 06700
    Mexico

    Site Not Available

  • Carpe Diem Centrum Medycyny Estetycznej

    Warszaw, Mazowieckie 02-661
    Poland

    Site Not Available

  • Hospital Germans Trias i Pujol

    Badalona, Barcelona [barcelona] 08916
    Spain

    Active - Recruiting

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, Catalunya [cataluña] 08041
    Spain

    Active - Recruiting

  • Hospital Universitari de Bellvitge

    L'Hospitalet de Llobregat, Barcelona [barcelona] 08907
    Spain

    Site Not Available

  • Centre de Recherche Saint-Louis

    Montréal, Quebec H1Y 3L1
    Canada

    Active - Recruiting

  • Istituto Dermopatico Immacolata

    Rome, Roma 00167
    Italy

    Active - Recruiting

  • Hamamatsu University Hospital

    Hamamatsu-shi, Shizuoka 431-3192
    Japan

    Active - Recruiting

  • Klinika Ambroziak Dermatologia

    Warszawa, Mazowieckie 02-953
    Poland

    Active - Recruiting

  • SANARE, s.r.o

    Svidnik, Prešovský KRAJ 089 01
    Slovakia

    Active - Recruiting

  • Hospital Universitario Infanta Leonor

    Madrid, Madrid, Comunidad DE 28031
    Spain

    Active - Recruiting

  • West Middlesex University Hospital

    Isleworth, England TW7 6AF
    United Kingdom

    Site Not Available

  • The Royal Melbourne Hospital

    Parkville, Victoria 3050
    Australia

    Site Not Available

  • Diex Recherche Quebec Inc.

    Quebec, G1V 4T3
    Canada

    Active - Recruiting

  • Universitätsklinikum Carl Gustav Carus Dresden

    Dresden, Sachsen 01307
    Germany

    Active - Recruiting

  • Magdeburger Company for Medical Studies and Services

    Magdeburg, Sachsen-anhalt 39104
    Germany

    Active - Recruiting

  • BAG Drs. Med. Quist PartG

    Mainz, Rheinland-pfalz 55128
    Germany

    Active - Recruiting

  • Derm-Surg Kft.

    Kaposvár, 7400
    Hungary

    Site Not Available

  • Pécsi Tudományegyetem Klinikai Központ

    Pécs, Baranya 7632
    Hungary

    Active - Recruiting

  • Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ

    Szeged, Csongrád 6720
    Hungary

    Site Not Available

  • Royalderm Agnieszka Nawrocka

    Warszawa, Mazowieckie 02-962
    Poland

    Site Not Available

  • Chang Gung Memorial Hospital at Kaohsiung

    Kaohsiung Niao Sung Dist, Kaohsiung 83301
    Taiwan

    Site Not Available

  • Innovaderm Research Inc.

    Montréal, Quebec H2X 2V1
    Canada

    Active - Recruiting

  • Centre de Recherche Dermatologique du Quebec metropolitain

    Quebec, G1V 4X7
    Canada

    Active - Recruiting

  • Rosenpark Research GmbH

    Darmstadt, Hessen 64283
    Germany

    Active - Recruiting

  • Universitaetsklinikum Carl Gustav Carus Dresden

    Dresden, Sachsen 01307
    Germany

    Active - Recruiting

  • Hautarztpraxis Dr. Neubauer

    Leipzig, Sachsen 04207
    Germany

    Active - Recruiting

  • HNO-Praxis Dr. Kugler in Magdeburg

    Magdeburg, Sachsen-anhalt 39104
    Germany

    Active - Recruiting

  • Tokyo Medical And Dental University Hospital

    Bunkyō, Tokyo 113-8519
    Japan

    Active - Recruiting

  • Osaka Habikino Medical Center

    Habikino, Osaka 583-8588
    Japan

    Active - Recruiting

  • Tokyo Medical University Ibaraki Medical Center

    Inashiki-gun, Ibaraki 300-0395
    Japan

    Active - Recruiting

  • Clinica de Enfermedades Cronicas y Procedimientos Especiales, SC

    Morelia, Michoacan 58249
    Mexico

    Site Not Available

  • Specjalistyczny Gabinet Dermatologiczny Aplikacyjno-Badawczy, Marek Brzewski, Paweł Brzewski spółka

    Kraków, Małopolskie 30-002
    Poland

    Active - Recruiting

  • ETG Warszawa

    Warszawa, Mazowieckie 02-677
    Poland

    Site Not Available

  • Fakultna nemocnica Trnava

    Trnava, Trnavský KRAJ 917 75
    Slovakia

    Active - Recruiting

  • AUDIKA

    Córdoba, Andalucía 14001
    Spain

    Active - Recruiting

  • Chang Gung Medical Foundation-Linkou Branch

    Taoyuan, 333
    Taiwan

    Site Not Available

  • Dr Rodney Sinclair Pty Ltd

    East Melbourne, Victoria 3002
    Australia

    Active - Recruiting

  • Royal North Shore Hospital

    St Leonards, New South Wales 2065
    Australia

    Site Not Available

  • First Affiliated Hospital of Kunming Medical University

    Kunming, Yunnan Sheng 650032
    China

    Active - Recruiting

  • Klinikum Bielefeld Rosenhöhe

    Bielefeld, Nordrhein-westfalen 33647
    Germany

    Active - Recruiting

  • Centro Regiomontano de Investigación

    Monterrey, Nuevo LEÓN 64060
    Mexico

    Site Not Available

  • Hospital Universitario Reina Sofia

    Cordoba, Andalucía 14004
    Spain

    Active - Recruiting

  • Hospital Universitari i Politecnic La Fe

    València, 46026
    Spain

    Active - Recruiting

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