Effects of Physical Exercise Timing On Strength and Cardiometabolic Health

Last updated: June 24, 2025
Sponsor: University of Basel
Overall Status: Completed

Phase

N/A

Condition

N/A

Treatment

Physical Exercise Intervention

Clinical Study ID

NCT06063135
EPOCH
  • Ages 60-80
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Physical exercise is well known to improve human health. Current guidelines provide recommendations on the frequency, intensity, type and duration of exercise. However, they do not provide recommendations for the time of day, exercise should be performed. This is surprising considering that the influence of timing of behaviors such as sleep or nutrition as well as the impact of the circadian timing system on health are well documented. Further, there is evidence for diurnal variation in maximum performance which enables individuals to exercise with different intensities at different times of day, which in the long term might affect physical adaptations to exercise. Thus, this research study investigates if exercise timing impacts human health.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • BMI 18.5 - 30 kg/m2

Exclusion

Exclusion Criteria:

  • Structured resistance training within the last six months

  • Ongoing shift work

  • Irregular bedtime (> 2 hours variation in habitual bed time)

  • Smoking

  • Travels across more than two time zones within the last four weeks

  • Inability to follow the study procedures (e.g. due to language barriers,psychological disorders, dementia, etc.)

  • Known pregnancy or lactating women

  • Participation in any other clinical trial within the last four weeks

  • Medical condition that is a contra indicator for resistance training, endurancetraining, or exercising until maximum exhaustion including insufficiently controlledblood pressure (systolic > 170 mmHg, diastolic > 100 mmHg), ongoing cancertreatment, unstable angina pectoris, uncontrolled bradyarrhythmia ortachyarrhythmia, severe uncorrected valvular heart disease, clinically relevantacute infection, any form of musculoskeletal injury, orthopedic problems ordecompensated cardiovascular disease

  • Insulin dependent diabetes

  • Participants using metformin

Study Design

Total Participants: 152
Treatment Group(s): 1
Primary Treatment: Physical Exercise Intervention
Phase:
Study Start date:
November 21, 2023
Estimated Completion Date:
June 24, 2025

Connect with a study center

  • University of Basel

    Basel, 4052
    Switzerland

    Site Not Available

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