Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and Compensated Cirrhosis

Inclusion Criteria:

Individuals must meet the following criteria to be eligible for study participation:

1. Must be at least 18 years old.

2. Must have a confirmed prior diagnosis of PBC

3. Evidence of cirrhosis

4. CP Score A or B

5. Females of reproductive potential must use at least 1 barrier contraceptive and asecond effective birth control method during the study and for at least 90 daysafter the last dose. Male individuals who are sexually active with female partnersof reproductive potential must use barrier contraception, and their female partnersmust use a second effective birth control method during the study and for at least 90 days after the last dose

6. Individuals must be able to comply with the instructions for study drugadministration and be able to complete the study schedule of assessments (SOA)

Exclusion Criteria:

Individuals must not meet any of the following criteria to be eligible for study participation:

1. Prior exposure to seladelpar

2. A medical condition other than PBC that, in the Investigator's opinion, wouldpreclude full participation in the study

3. History of liver transplantation or actively listed for cadaveric or planned livingdonor transplant.

4. Decompensated cirrhosis

5. Evidence of portal vein thrombosis based on imaging at time of Screening by Dopplerultrasound or prior evidence by CT or MRI

6. Hospitalization for liver-related complication within 12 weeks of Screening

7. Laboratory parameters at Screening:

8. Alkaline phosphatase (ALP) < 1.5× Upper limit of normal (ULN) or ≥ 10×ULN

9. Alanine aminotransferase (ALT) or Aspartate aminotransferase (AST) ≥5×ULN

10. Total bilirubin (TB) ≤ 0.6 × ULN or ≥ 5 × ULN

11. Platelet count ≤50×10^3/µL

12. Albumin ≤2.8 g/dL

13. Estimated glomerular filtration rate (eGFR) <45 mL/min/1.73 m^2

14. MELD score >12. For individuals on anticoagulation medication, baselineInternational normalized ratio (INR) determination for MELD score calculationshould take anticoagulant use into account, in consultation with the MedicalMonitor.

15. Serum alpha-fetoprotein (AFP) >20 ng/mL

16. INR >1.7

17. CP-C cirrhosis

18. History or presence of other concomitant liver diseases