Phase
Condition
Cardiac Surgery
Anemia
Treatment
Saline
Iron sucrose, Human Erythropoietin Injection, Vitamin C
Standard Medical Care
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Participants must be at least 18 years of age.
Major cardiac surgery should encompass procedures such as coronary artery bypassgrafting (CABG), valve surgery, or a combination of both.
Iron deficiency anemia is defined as having a ferritin level below 100 μg/L or aferritin level below 300 μg/L accompanied by a transferrin saturation below 25%.Additionally, hemoglobin levels should range between 90 and 130 g/L for men orbetween 90 and 120 g/L for women.
The American Society of Anesthesiologists (ASA) classification should fall withinGrade 1-3.
Prior to participation, the patient or their legal representative must provideinformed consent.
Exclusion
Exclusion Criteria:
Contraindications for the administration of iron sucrose, ascorbic acid, or rHuEPO.
Presence of a temperature exceeding 37.5 °C or the utilization of non-prophylacticantibiotics.
Individuals with a weight equal to or less than 50kg.
Individuals with a family history of haemochromatosis or thalassaemia, or those witha transferrin saturation level exceeding 50% or a documented history of ironoverload.
Presence of other known haematological disorders such as folic acid or vitamin B12deficiency, haemolytic anaemia, haemoglobinopathies, iron granulocytic anaemia, G6PDdeficiency, etc.
Requirement for emergency surgical intervention.
Severe hepatic or renal impairment, ALT >3 times the upper limit of normal value orAST >3 times the upper limit of normal value, creatinine >1.5 times the upper limitof normal value
Pregnant or lactating women
history of blood transfusion, intravenous iron or ascorbic acid use within 12 weeksprior to surgery
Acute blood loss, gastrointestinal bleeding, etc. in the preoperative period.
Study Design
Study Description
Connect with a study center
The Second Affiliated Hospital of Zhejiang University anesthesiology department
Hangzhou, Zhejiang 310000
ChinaActive - Recruiting
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