A Study to Assess the Efficacy, Safety and Pharmacokinetics of EYU688 in Patients With Dengue Fever

Inclusion Criteria:

• Male or female, 18 - 60 years old (inclusive).

• History or presence of fever (≥ 38°C). At least one of the following criteriaindicating dengue infection:

• Nausea or vomiting.

• Presence of rash, aches or pains including headache, muscle or joint pain.

• Onset of fever ≤ 48 hours prior to treatment start.

• Positive test on dengue fever.

Exclusion Criteria:

• Participants with any of abnormalities of clinical laboratory parameters.

• Usage of any anticoagulant drugs.

• Current significant medical conditions or illness that the investigator considersshould exclude the participants, especially those that require continuation of othermedications likely to have an interaction with the study drug.

• Pregnant or nursing (lactating) women.

• Clinical signs and symptoms for severe dengue according to Dengue Guideline (WHO

2009. at screening.

• Participants with any of the following abnormalities of clinical laboratoryparameters at screening:

• Hemoglobin <12.0 g/dL in males; <11.0 g/dL in females

• Hematocrit >52 % in males; >46 % in females

• Absolute neutrophil count <1500/μL

• Platelet count <80,000/mm3

• Creatinine >165 μmol/L in males; >130 μmol/L in females

• Serum creatine kinase > 600 U/L

• ALT, AST levels more than 1.5X upper limit of normal (ULN)

• Total bilirubin >24 μmol/L

• Usage of PPIs (proton pump inhibitor) which could affect absorption of EYU688 due tostomach pH value increase up to 48 hours prior to screening.

• Women of child-bearing potential, defined as all women physiologically capable ofbecoming pregnant, unless they are using highly effective methods of contraceptionduring dosing and for 4 days after stopping of investigational drug.

• History or long-QT syndrome, or clinically significant ECG abnormalities, or any ofthe following ECG abnormalities at screening:

• QTcF > 450 msec (males)

• QTcF > 460 msec (females)

Other protocol-defined inclusion/exclusion criteria may apply.