Brain Neuronal Networks, Chemosensory and Trigeminal Functions in Allo-HSCT

Last updated: March 25, 2025
Sponsor: University of Oslo
Overall Status: Active - Recruiting

Phase

N/A

Condition

Bone Marrow Transplant

Anemia

Treatment

N/A

Clinical Study ID

NCT06003660
282886
  • Ages 30-50
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The goal of this prospective, cohort study is to learn about smell, taste and trigeminal dysfunction in patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT). The research team hypothesizes that treatment with allo-HSCT will induce:

  • Distortion of taste and smell and trigeminal functions like cooling, tingling, and burning sensations.

  • Reduced saliva production leading to oral dryness and dental caries.

  • Changes in the connectivity of the taste-, smell- and pain-cortical brain regions.

Eligibility Criteria

Inclusion

Inclusion Criteria:

• patients receiving myeloablative conditioning for a first-time allo-HSCT and diagnosed with either a leukemia or a myelodysplastic syndrome

Exclusion

Exclusion Criteria:

  • disorders affecting the oral cavity including poor tooth-status

  • those using drugs affecting the gustatory/olfactory functions

  • those with brain disorders

  • those who have a chronic disorder affecting the immune system, have cancer or whoare pregnant.

Study Design

Total Participants: 70
Study Start date:
August 10, 2023
Estimated Completion Date:
June 30, 2026

Study Description

Participants will undergo various tests:

  • Smell function assessment with Sniffin' Sticks.

  • Taste function assessment with Taste Strips.

  • Oral trigeminal function assessment with von Frey filaments .

  • Salivary assessment with the Summated Xerostomia Inventory-Dutch questionnaire.

  • Salivary flow will be measured using salivary flow rate - stimulated whole saliva (SWS).

  • A clinical oral examination will be done to obtain a Clinical Oral Dryness Score.

  • Qualitative smell, taste and trigeminal dysfunction will be assessed using a questionnaire.

  • Radiological and clinical examinations will be performed to evaluate dental and oral mucosal status.

  • Quality of life using questionnaire.

  • Nutritional status using questionnaire.

  • Magnetic resonance imaging of the brain will be taken to capture regions-of-interest for the three different networks of interest; (i) the gustatory network reflecting changes in taste perception, (ii) the olfactory network, related to the changes in smell, and (iii) the pain matrix reflecting pain.

There will be a comparisons between the patients and healthy controls.

Connect with a study center

  • University of Oslo

    Oslo, 0254
    Norway

    Active - Recruiting

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