BE WELL With Migraine: Brain Education and WELLness With Migraine

Last updated: May 28, 2025
Sponsor: Wake Forest University Health Sciences
Overall Status: Active - Recruiting

Phase

N/A

Condition

Chronic Pain

Pain (Pediatric)

Headaches

Treatment

Brain Education and WELLness with Migraine Group B

Brain Education and WELLness with Migraine Group A

Clinical Study ID

NCT05987592
IRB00079570
R01AT011502
  • Ages > 18
  • All Genders

Study Summary

The goal of this randomized clinical trial is to evaluate two different non-drug, virtual treatment options designed to improve the lives of patients with migraine. Both interventions involve 8 weekly sessions and an online platform with additional content and learning. Participants can stay on all their medications during this study. Information from this study may help determine how to better treat migraine.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosis of migraine with or without aura by with headache frequency of 4-20days/month

  • At least 1 year of migraine

  • At least 18 years old

  • Able to participate in 8 weekly online classes

  • Willingness to complete baseline headache logs

  • Headache-related disability (Headache Impact Test (HIT)-6) score >50

  • Fluent in English

  • Completion of technology onboarding with the online platform

  • Pregnant women who are less than or equal to 16 weeks gestation at enrollment areallowed to participate

Exclusion

Exclusion Criteria:

  • Major unstable medical/psychiatric condition that could be unsafe for participantsor for the group environment.

  • Medication overuse headache, with migraine treatment

  • Pregnant women who are more than 16 weeks gestation at enrollment

  • Unstable migraine treatment at enrollment: any preventive treatment (oral orinjectable medication or neuromodulatory device) started within 12 weeks OR acutetreatment within 4 weeks to ensure stability

  • Unwillingness to maintain stable current medication dosages for study duration

  • Failure to complete baseline headache logs

  • Heavy alcohol and illicit drug use

  • Participation in another intervention clinical trial or one that would interfere inthis study

  • Experience with stress reduction training (daily meditation practice, regular use ofa mindfulness app, or prior experience with MBSR)

  • Any, and all other diagnoses or conditions which, in the opinion of the siteinvestigator, would prevent the patient from being a suitable candidate for thestudy or interfere with the medical care needs of the study participant:COVID-positive test within 30 days of enrollment

Study Design

Total Participants: 286
Treatment Group(s): 2
Primary Treatment: Brain Education and WELLness with Migraine Group B
Phase:
Study Start date:
July 31, 2024
Estimated Completion Date:
June 30, 2027

Study Description

This study involves 8 weekly virtual sessions & an online platform designed to improve the lives of patients with migraine. Participants from across the United States with migraine may be eligible to participate. This study does not require any in-person visits. All assessments and surveys will be completed virtually and/or online. Participants will independently complete an initial online screen. Participants will attend a scheduled phone or videoconferencing call with a study team member to complete the baseline assessment and learn how to use the online platform. Participants will keep an online daily headache log and complete several online surveys throughout the study.

Connect with a study center

  • Cambridge Health Alliance - Center for Mindfulness and Compassion

    Cambridge, Massachusetts 02141
    United States

    Site Not Available

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina 27157
    United States

    Active - Recruiting

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohio 45229-3039
    United States

    Site Not Available

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