Diuretic Efficacy of Aminophylline and Furosemide Combination vs Furosemide Alone in Critically Ill Adults

Last updated: July 9, 2023
Sponsor: University of Malaya
Overall Status: Active - Recruiting

Phase

2/3

Condition

Kidney Failure

Kidney Disease

Renal Failure

Treatment

Frusemide

Aminophylline

Clinical Study ID

NCT05933642
202334-12198
  • Ages > 18
  • All Genders

Study Summary

The goal of this RCT is to compare the effectiveness of aminophylline and furosemide combination vs furosemide alone in producing effective diuresis in critically ill adults in ICU. ICU patients with the need of improved diuresis will be recruited and given either infusion of aminophylline and furosemide combination or furosemide alone, and their hourly urine output will be monitored to compare their effectiveness.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients aged 18 years old and above who are admitted to the ICU of UMMC during thestudy period
  • Oliguric patients, with the need for improved diuresis at clinician discretion -defined as urine output <0.5ml/kg/hour

Exclusion

Exclusion Criteria:

  • Patient refusal for participation of study
  • Patients with known hypersensitivity reaction to aminophylline or furosemide
  • Patients with history of tachyarrhythmias, seizures, aspartate aminotransferase oralanine aminotransferase > 3 times normal, or hypothyroidism. Patient with existing peptic ulcer disease or coagulopathy with INR > 1.5

Study Design

Total Participants: 132
Treatment Group(s): 2
Primary Treatment: Frusemide
Phase: 2/3
Study Start date:
July 02, 2023
Estimated Completion Date:
December 31, 2023

Connect with a study center

  • University of Malaya

    Kuala Lumpur, 50603
    Malaysia

    Active - Recruiting

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