Open Trial of Trauma-focused Psychodynamic Psychotherapy for People Living With HIV and PTSD

Last updated: May 1, 2025
Sponsor: Montefiore Medical Center
Overall Status: Active - Recruiting

Phase

N/A

Condition

Hiv

Post-traumatic Stress Disorders

Treatment

Trauma-focused psychodynamic psychotherapy

Clinical Study ID

NCT05929911
2023-15016
P30AI124414
  • Ages 18-65
  • All Genders

Study Summary

People living with HIV (PLWH) have a higher rate of post-traumatic stress disorder (PTSD) diagnosis than the general population. Comorbid PTSD is also associated with negative HIV-related health outcomes. Unfortunately, little outcome research has examined the usefulness of PTSD treatments for PTSD. This pilot study adapts for PLWH a non-exposure based psychotherapy for PTSD focused on reflecting on one's emotions and relationships and understanding and working through how trauma may have disrupted them. The study team is interested in better understanding the needs of PLWH with PTSD, learning whether PLWH with PTSD find this treatment acceptable and helpful, and beginning to understand the relationship between HIV-related health factors (e.g., inflammation and stress biology) and PTSD, and how these health factors may improve during treatment.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosis of DSM-5 defined PTSD, per the Clinician Administered PTSD Scale & CAPS-5total severity score greater than or equal to 25

  • HIV diagnosis (by medical records or HIV testing)

  • Stable psychiatric/psychotropic medication for >=2 months and ongoing duringtreatment

Exclusion

Exclusion Criteria:

  • Psychosis

  • Bipolar I

  • Acute suicidality

  • Current substance use disorder

  • Organic mental syndrome or intellectual disability

  • Unstable non-HIV medical conditions

Study Design

Total Participants: 20
Treatment Group(s): 1
Primary Treatment: Trauma-focused psychodynamic psychotherapy
Phase:
Study Start date:
April 26, 2024
Estimated Completion Date:
April 30, 2026

Connect with a study center

  • Albert Einstein College of Medicine

    Bronx, New York 10461
    United States

    Active - Recruiting

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