MRI Neurofeedback and Brain Circuits Related to Motivation in Healthy Participants

Inclusion Criteria:

• Age between 18 and 45 years

• Male or female

• Right-handed

• In good general health

• Women of childbearing capacity: use of effective method of birth control

Exclusion Criteria:

• Current or diagnosis within past six months of an DSM-V Axis I or Axis II disorder (self-reported)

• CES-D score of 20 or higher (indicating significant current depression symptoms)

• Current or past six month use of prescription medications indicated for psychiatricconditions (e.g.,depression, anxiety)

• Current serious medical illness (self-reported)

• Head injury resulting in loss of consciousness

• For participants age > 59 years, a total scaled score < 8 on the Dementia RatingScale-2.

• A clinically-defined neurological disorder including, but not limited to:

• Any condition likely to be associated with increased intracranial pressure

• Space occupying brain lesion

• History of stroke

• Transient ischemic attack within two years

• Cerebral aneurysm

• Dementia

• Mini Mental Status Exam (MMSE) score of <24

• Parkinson's disease

• Huntington's disease

• Multiple sclerosis

• Presence of cochlear implants or other implanted electronic devices or non-removablemetal (e.g., non-removable piercing, IUD)

• History of an eye injury involving metal. Participants who worked with metal may beallowed to participate on a case-by-case basis with prior written approval fromBIAC.

• Claustrophobia or unwillingness to tolerate the confinement associated with being inthe MRI scanner.

• Weight of more than 250 pounds