Long-term, Open-label Study of SAR447537 (INBRX-101) in Adults With Alpha-1 Antitrypsin Deficiency Emphysema

Inclusion Criteria:

1. Males or females 18-80 years of age, inclusive, at the time of screening

2. Diagnosis of AATD

3. Evidence of emphysema secondary to AATD

4. FEV1 of ≥ 30% predicted at screening and post-bronchodilator FEV1/FVC<0.7

5. Current non-smoking status

Exclusion Criteria:

For newly identified participants

1. Receipt of A1PI augmentation therapy within 5 weeks prior to the first dose of studydrug

2. Known or suspected allergy to components of SAR447537, A1PI or human IgG

3. Uncontrolled diabetes mellitus despite adequate antidiabetic pharmacologic treatmentwith a screening HbA1c value ≥9%

4. Received IV immunoglobulins, monoclonal antibodies and/or other biologic therapieswithin 30 days

5. On waiting list for lung or liver transplant

6. Acute respiratory tract infection or COPD exacerbation within 4 weeks prior to orduring screening

7. Evidence of decompensated cirrhosis

8. Active cancers or has a history of malignancy within 5 years prior to screening

9. History of unstable cor pulmonale

The above information is not intended to contain all considerations relevant to a participant's potential participation in a clinical trial.