Egyptian Hypertrophic Cardiomyopathy Program

Last updated: May 23, 2023
Sponsor: Magdi Yacoub Heart Foundation
Overall Status: Active - Recruiting

Phase

N/A

Condition

Heart Defect

Congestive Heart Failure

Circulation Disorders

Treatment

N/A

Clinical Study ID

NCT05884892
AHC-HCM
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Egyptian HCM program aims at defining incidence, severity, phenotype, genotype and determinants of the disease in Egypt, and providing state-of-the-art treatment strategies including medical, surgical and interventional procedures which are patient- and disease-specific.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • All patients diagnosed with hypertrophic cardiomyopathy (index patients) who arewilling and consented to participate in the registry.
  • All family members of index patients who are willing and consented to participate inthe registry.

Exclusion

Exclusion Criteria:

  • Refusal to consent to participate in the registry program.

Study Design

Total Participants: 2000
Study Start date:
January 01, 2014
Estimated Completion Date:
January 01, 2030

Study Description

This project aims to:

  • Define incidence, severity, phenotype, genotype and determinants of the disease in Egypt.

  • Characterise the phenotype and genotype of several large cohorts with inherited muscle disease and their relatives.

  • Provide state-of-the-art treatment strategies including medical, surgical and interventional procedures which are patient- and disease-specific.

  • Study the basic mechanisms responsible for the different phenotypes at a molecular and cellular level including genotype-phenotype correlation.

  • Provide a special focus for studying patients who are genotype positive and phenotype negative which we believe could yield critical data regarding the evolution of the disease.

  • Develop sophisticated laboratory studies for single cell electrophysiology and immunocytochemistry and others focusing on the explanted human material from the surgical program.

  • Define the role of microvascular coronary artery in the development and progression of the disease.

  • Training Egyptian cardiologists, cardiac surgeons and scientists on state-of-the-art diagnosis and management of heart muscle disease including the latest developments in imaging, novel surgical techniques, coronary physiology, next generation sequencing, bioinformatics and cellular electrophysiology.

Connect with a study center

  • Aswan Heart Centre - Magdi Yacoub Heart Foundation

    Aswan,
    Egypt

    Active - Recruiting

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