Evaluation of the Medical Benefit of Spa Therapy on Fibrosis After Postoperative Radiotherapy for Breast Cancer

Inclusion Criteria:

• Female

• Age ≥ 18 years

• In situ or invasive breast cancer

• DLQI ≥ 6 (at least moderate effect on patient's life)

• General status WHO 0-1

• Post-operative radiotherapy completed at least 6 months ago (with no maximum postradiotherapy delay)

• Unilateral breast radiotherapy

• Skin or soft tissue toxicity (- modules: Skin and subcutaneous tissue disorders /Musculoskeletal disorders / Reproductive organs and breast disorders) CTCAE v4.0grade ≥ 2

• No inflammatory or infectious flare at inclusion

• Female of childbearing potential: negative urine pregnancy test at inclusion

• Patient informed and signed consent

• Affiliation to a social security systeme or equivalent

Exclusion Criteria:

• Progressive phase of cancer

• Metastatic disease

• Patient undergoing specific treatment for breast cancer (except adjuvant hormonetherapy and/or adjuvant herceptin)

• Bilateral breast/parietal radiotherapy

• Breast prosthesis wearer

• Obvious skin ulceration in the treated breast

• Contraindication to spa treatment (acute inflammatory disease, active infections,heart failure with NYHA stage > 1, chronic respiratory failure, labile hypertension,bullous disease)

• Chronic progressive dermatological disease

• Women who are pregnant or likely to become pregnant within 6 months or who arebreastfeeding

• Persons deprived of liberty or under guardianship