Study Using Hyperpolarized 13C-Pyruvate Magnetic Resonance Spectroscopic Imaging in Patients with Pancreatic Cysts Undergoing Surgical Resection

Last updated: January 28, 2025
Sponsor: M.D. Anderson Cancer Center
Overall Status: Suspended

Phase

1

Condition

Pancreatitis

Treatment

Hyperpolarized 13-C-pyruvate

Clinical Study ID

NCT05873699
2022-0854
NCI-2023-04096
  • Ages > 18
  • All Genders

Study Summary

To learn if Hyperpolarized C-Pyruvate Magnetic Resonance (HP-MR) Spectroscopic Imaging can help doctors detect low-risk (benign) and high-risk (malignant) cysts.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients ≥ 18 years old. Patients under 18 are excluded due to their potentialinability to understand and consent independently to the methods required for thestudy drug use and its potential risks and benefits.

  • Patients with pancreatic cyst/s

  • Patients who will undergo surgical resection (or cyst wall biopsy) of pancreaticcysts

  • Patients able to understand and willing to sign a written informed consent document

  • Both English-speaking and non-English-speaking patients are eligible forparticipation

Exclusion

Exclusion Criteria:

  • Contraindication to MRI

  • Electrically, magnetically, or mechanically activated implants that would precludeMRI

  • Allergy to Gadavist IV contrast

  • History of cardiac arrhythmias

  • Pregnancy or breastfeeding women

  • Women of child-bearing age that are sexually active and not using birth control

  • Cognitively impaired individuals

  • Weight above 260 pounds (lbs)

Study Design

Total Participants: 10
Treatment Group(s): 1
Primary Treatment: Hyperpolarized 13-C-pyruvate
Phase: 1
Study Start date:
August 18, 2023
Estimated Completion Date:
January 31, 2027

Study Description

Primary Objectives:

To explore the use of HP-MR in patients with cystic lesions of the pancreas undergoing surgical resection. Patients will undergo HP-MR prior to surgical resection (or cyst wall biopsy) and kpl values will be determined to evaluate metabolic activity. Pathology will then determine whether the cyst was of benign/low risk or malignant/high risk nature. The ability for increased kpl to detect an invasive carcinoma will be explored by estimating the association between lesions' kpl values and lesions' pathological results.

Secondary Objectives:

  • A kpl inflection point, or threshold, will then be explored to estimate the association with malignant/high risk cyst. This threshold value would then undergo further validation in future studies to calculate the sensitivity and specificity of this value.

  • Correlate HP-MR findings to tissue metabolomics (ex vivo): In all patients who undergo surgical resection, a small surgical sample will be supplied for ex vivo metabolomics. NMR metabolomics will be used to measure lactate, creatine, choline, phosphocholine, glycerophosphocholine, and alanine within the tissue sample. The highest lactate levels should be found in the most aggressive tumors, which also should correlate to high kpl.

  • Correlate HP-MR findings to blood and cyst fluid biomarkers: Blood samples taken prior to surgical resection will be analyzed for CA19-9 and CEA. If the patient has a cystic fluid aspiration prior to surgical resection, then CA19-9, amylase and CEA will also be measured in these samples. These biomarkers will be compared to findings from HP-MR and pathologic results.

  • Correlate HP-MR findings to immunohistochemical staining for LDH-A and HIF-1α: Tissue taken from pathology samples for metabolomics will also undergo immunohistochemical staining for LDH-A and HIF-1α.

  • Correlate gut and tissue microbiome with HP-MR findings: Microbiome studies may be performed under the auspice of another protocol but could be analyzed under this protocol in relation to HP-MR findings. PA 16-0911 allows for the collection of stool in patients with cysts of the pancreas for gut microbiome investigation in relation to the development of pancreatic cancer.

  • To explore the safety and tolerability of HP-MR in patients with cystic lesions of the pancreas undergoing surgical resection or cyst wall biopsy.

Connect with a study center

  • M D Anderson Cancer Center

    Houston, Texas 77030
    United States

    Site Not Available

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