Stroke Rate in Patients With Blunt Cerebrovascular Injury (BCVI) Treated With Oral Acetylsalicylic Acid (ASA) 81 mg Versus ASA 325 mg (BASA).

Last updated: January 14, 2025
Sponsor: Loma Linda University
Overall Status: Active - Recruiting

Phase

4

Condition

N/A

Treatment

Aspirin 325Mg Tab, Aspirin 81Mg Tab

Clinical Study ID

NCT05868525
5220429
  • Ages > 18
  • All Genders

Study Summary

The goal of this clinical trial is to compare difference between Aspirin 81 mg and Aspirin 325 mg in preventing strokes in patients with head and neck vessels injury.

The main questions it aims to answer are:

  • If Aspirin 81 mg efficacy in prevention of stroke in patients with head and neck vessels injury is not lower than and Aspirin 325 mg.

  • If rate of hemorrhagic complications in patients with head and neck vessels injury taking Aspirin 81 mg is not higher than patients that take Aspirin 325 mg.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age ≥18

  • All patients with blunt cerebrovascular injury are diagnosed by computed tomographyangiography (CTA) upon admission

Exclusion

Exclusion Criteria:

  • Age <18

  • Pregnant women

  • No enteral route access for Aspirin administration

  • Patients who are on Heparin drip or other full dose anticoagulation when BCVIdiagnosed

  • Patients who are on other Anti-Platelets aside from Aspirin when BCVI diagnosed

  • Patients with BCVI grade 5 injury based on Biffl classification

  • Presence of any contraindication or history of allergy to Aspirin

  • Patient with the diagnosis of acute stroke at the time of BCVI diagnosis matchingthe injured vessel territory on imaging

  • Patients with acute spinal trauma that needs surgical intervention

Study Design

Total Participants: 98
Treatment Group(s): 1
Primary Treatment: Aspirin 325Mg Tab, Aspirin 81Mg Tab
Phase: 4
Study Start date:
August 23, 2023
Estimated Completion Date:
December 31, 2025

Connect with a study center

  • Loma Linda University Medical Center

    Loma Linda, California 92354
    United States

    Active - Recruiting

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