A Urine Sample Collection Study in Apparently Healthy Adults and Adults With Chronic, Stable Morbidities

Cohort A Inclusion Criteria:

1. Apparently healthy adults (age > 21 years);
2. Provide written informed consent for study participation.

Exclusion Criteria:

1. Any known or suspected acute illness or condition - including acute infections - atthe time of enrollment or within the previous 30 days;
2. Any known or suspected significant new onset or chronic morbid medical condition suchas those listed in the inclusion criteria for Cohort B;
3. Trauma-related surgery within the last 6 months;
4. Any surgery, hospitalization or institutionalization (such as in a nursing home)during the previous 3 months;
5. Received any blood product transfusion within the previous 2 months;
6. Pregnant women or children;
7. Prisoners or institutionalized individuals;
8. Already provided a urine sample for this study. Cohort B Inclusion Criteria:
9. Adults (age > 21 years);
10. One or more of the following chronic, stable morbid conditions: i. Active cancer ii. Arrhythmia (atrial fibrillation, heart block, ventricular tachycardia) iii. Chronic coagulation abnormality iv. Chronic obstructive pulmonary disease (includingemphysema, chronic bronchitis, and asthma) v. Chronic pancreatitis vi. Chronic renalinsufficiency vii. Congestive heart failure viii. Coronary artery disease ix. Diabetesmellitus (Type 1 or Type 2) x. Gout xi. Hyper- or hypothyroidism xii. Hyperlipidemia (includes hypercholesterolemia) xiii. Hypertension xiv. Immunocompromised xv. Inflammatorybowel disease (including Crohn's disease and ulcerative colitis) xvi. Liver cirrhosis xvii.Neuromuscular disease xviii. Peripheral vascular disease (a.k.a. peripheral artery disease) xix. Polycystic kidney disease xx. Rheumatoid arthritis xxi. Systemic Lupus Erythematosus c. Provide written informed consent for study participation. Exclusion Criteria:
11. Any known or suspected acute illness or condition - including acute infections - atthe time of enrollment or within the previous 30 days;
12. Any new onset or unstable morbidities;
13. Trauma-related surgery within the last 6 months;
14. Any surgery, hospitalization or institutionalization (such as in a nursing home)during the previous 3 months;
15. Received any blood product transfusion within the previous 2 months;
16. Pregnant women or children;
17. Prisoners or institutionalized individuals;
18. Already provided a urine sample for this study.