Relapsed Follicular Lymphoma Randomised Trial Against Standard ChemoTherapy

Inclusion Criteria:

1. Biopsy proven relapsed or refractory CD20 positive, grade 1-3a follicular lymphoma (biopsy within 3 months of trial entry)
2. Aged 18 years or over
3. Advanced disease that in the opinion of the treating physician requires treatment
4. Patient suitable for standard available therapy at the Investigator's discretion
5. Prior therapy with at least one line of immunochemotherapy. Previous radiotherapy atany time is permitted and will not count as a line of therapy. Previous rituximabmonotherapy is also permitted as long as patients have at any time also received atleast one line of immunochemotherapy
6. Assessable disease by PET-CT (at least one involved node with long diameter >1.5cm, orextranodal lesion >1cm )
7. ECOG performance status of 0, 1 or 2 at trial entry
8. Adequate organ function defined as; i. ANC ≥ 1.0 x 109/L (growth factor use ispermitted) ii. Platelet count ≥ 75 x 109/L, or ≥ 50 x 109/L if bone marrowinfiltration or splenomegaly iii. ALT and AST level ≤3 x ULN iv. Direct bilirubinlevel ≤ 2 x ULN, unless due to Gilbert's syndrome v. CrCl ≥ 50mL/min (byCockcroft-Gault formula) vi. PT, INR and aPTT ≤ 1.5 x ULN, unless receivinganticoagulation vii. LVEF within normal limits by MUGA or echocardiography
9. Able to provide written informed consent
10. Women of childbearing potential (or their partners) must use an effective form ofcontraception

Exclusion Criteria:

1. Current (or within 1 year) transformation to high grade lymphoma, including grade 3bfollicular lymphoma (patients with historical high-grade transformation over 1 yearago are eligible)
2. Non-Fluorodeoxyglucose (FDG) avid disease
3. Prior allogenic stem cell transplantation (SCT) or solid organ transplant
4. Prior treatment with lenalidomide
5. Treatment with CAR-T therapy within 100 days of starting trial treatment
6. SCT or maintenance therapy planned within 24 weeks of starting treatment (patientsplanning SCT/maintenance after at least 24 weeks of treatment are eligible)
7. Immunochemotherapy with a platinum-containing regimen planned
8. Known serological positivity for HIV or uncontrolled HCV
9. Hepatitis B surface antigen (HBsAg) positive and/or detectable viral DNA. Patientspositive for Hepatitis B core antibody (anti-HBc) but viral DNA negative are eligible
10. Other malignancy within 2 years of enrolment, excepting cervical carcinoma stage 1B orless, non-invasive basal cell or squamous cell skin carcinoma, non-invasive,superficial bladder cancer, prostate cancer with a current PSA level <0.1ng/mL, anycurable cancer with a CR of > 2 years duration
11. Active systemic infection requiring treatment
12. Current or prior CNS involvement with lymphoma
13. History of allergy or anaphylaxis to anti-CD20 monoclonal antibody therapy
14. Known hypersensitivity to any of the experimental arm IMPs. Patients with a knownhypersensitivity to a control arm regimen may still be eligible if they have nohypersensitivity to other potential control arm IMPs.
15. Serious medical or psychiatric illness likely to interfere with participation in thisclinical study
16. Recent cancer treatment (chemotherapy, immunotherapy, biological therapy) within 4weeks of starting trial treatment; systemic steroid treatment (prednisolone > 10mgdaily (or equivalent)) within 7 days of cycle 1 day 1 dosing
17. Unwilling to use appropriate contraception methods whilst on study treatment and for 12 months following end of treatment (or 18 months for female patients whose ICTregimen contains obinutuzumab)
18. Women who are pregnant or breastfeeding
19. Prior treatment with the experimental therapy under investigation
20. Major surgery within 30 days of starting treatment
21. Severe arrhythmias, heart failure, previous myocardial infarction, acute inflammatoryheart disease for ICT regimen containing doxorubicin, or severe heart failure (NewYork Heart Association Class IV) or severe, uncontrolled cardiac disease for ICTregimen containing rituximab