A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors

Inclusion Criteria:

• ≥18 years old

• Histologically or cytologically confirmed advanced or metastatic malignancies asdefined in the protocol.

• Part 1: Participants must have experienced disease progression after treatment with,be intolerant to, or be ineligible for, or refused available therapies, includinganti-PD-(L)1 or anti-CTLA4 therapy if applicable, that are known to confer clinicalbenefit. Part 2: depending on cohort, participants may have received or not priortreatment for the malignancy under study.

• ECOG performance status score of 0 or 1.

• Willingness to undergo pre- and on-treatment tumor biopsy (core or excisional).Biopsies are mandatory depending on the cohorts.

• Presence of measurable disease according to RECIST v1.1.

Exclusion Criteria:

• Any known additional malignancy that is progressing or requires active treatment, orhistory of other malignancy within 2 years.

• Not recovered to ≤ Grade 1 or baseline from residual toxicities of prior therapy.

• Has active autoimmune disease requiring systemic immunosuppression withcorticosteroids.

• Brain or CNS metastases untreated or that have progressed.

• History of organ transplant, including allogeneic stem cell transplantation.

• History of clinically significant or uncontrolled cardiac disease.

• Active HBV, active HCV, or HIV positive.

• Is on chronic systemic steroids (> 10 mg/day of prednisone or equivalent).

• Chronic or current active infectious disease requiring systemic antibiotics,antifungal, or antiviral treatment

• Participants that have been initiated on or had modifications in anticoagulationtherapies within the last 3 months prior to first dose of treatment.

• Significant concurrent, uncontrolled medical condition, eg:

• Cardiovascular: Participants with known vasculitis, aneurisms, and othervascular malformations of clinical significance or history of myocarditis.

• Gastrointestinal: Any bowel obstruction within 60 days prior to C1D1.

• Participants with adequate laboratory values within the protocol defined ranges.

Other protocol-defined Inclusion/Exclusion Criteria may apply.