Treatment of Urethral Stricture With Urethral Drug Ball

Inclusion Criteria:

• 1. Age ≥ 18 and ≤ 85 years old, male patients;

2. Urethral stricture was confirmed by transurethral angiography, and the length ofstricture was less than 2 cm;
3. Maximum urine flow rate (Qmax)<15 ml/s;
4. There are obvious symptoms of urinary tract stricture such as slow urine rheology,difficulty in urination and incomplete urination;
5. International Prostate Symptom Score (IPSS) ≥ 13;
6. The guide wire must be able to pass through the stenosis segment;
7. Patients who can understand the purpose of the trial, voluntarily participate inand sign the informed consent form, can independently complete effectivequestionnaires, and are willing to conduct clinical follow-up according to theresearch requirements.

Exclusion Criteria:

• 1. Patients with multiple stenotic lesions;

2. Patients with a history of allergy to paclitaxel and contrast agents, or patientsundergoing treatment with drugs that may antagonize paclitaxel;
3. Patients who have undergone hypospadias repair, urethroplasty, stricture expansionor incision in the past 3 months;
4. Urethral stricture caused by the following causes: bacterial urethritis, untreatedgonorrhea, lichen sclerosus or dry glans obliterans;
5. There are other diseases that can cause lower urinary tract symptoms, such asoveractivity of bladder, neurogenic bladder dysfunction, etc;
6. There are adverse factors for catheter insertion;
7. Patients with artificial penis or urethral sphincter, or urethral or prostatestent;
8. Patients who have been diagnosed with urethra cancer, bladder cancer cancer orprostate cancer, or who have experienced pelvic radiotherapy in the past 2 years;
9. For patients with severe renal insufficiency, their serum creatinine is more than 2.5mg/dL or they are undergoing hemodialysis;
10. Patients with severe lung disease, cardiovascular disease, coagulation dysfunctionand contraindication of anesthesia;
11. Patients with poor control of diabetes (hemoglobin A1c>8.0%);
12. Patients with active urinary stones in the past 6 months;
13. Patients who are not suitable for direct vision internal urethrotomy;
14. Patients with pregnancy preparation plan;
15. Patients who are participating in clinical trials of other drugs or medicaldevices and have not reached their main endpoint;
16. Patients who cannot participate in the clinical trial due to other reasonsconsidered by the investigator.