Investigating Geographic Atrophy Insights (i-GAIN) Natural History Study

Inclusion Criteria:

1. Clinical diagnosis of bilateral GA due to AMD as confirmed by fundoscopy and imagingat Screening
2. GA lesion sizes of ≥ 1.25 mm2 to ≤ 17 mm2 (approximately 1-7 disc diameters) in atleast one eye as per Central Reading Center
3. Willing and able to provide written informed consent
4. Male or female aged 65 years and over

Exclusion Criteria:

1. History of neovascular (wet) AMD or presence of neovascular (wet) AMD in either eyeconfirmed by fundoscopy at screening and/or any pre-existing retinal imaging
2. History of intravitreal (IVT) injection in the study eye. Note: Intravitreal treatmentwith pegcetacoplan (Syfovre®) and avacincaptad pegol (IzervayTM) if approved withinthe participant's country of origin AND if deemed necessary by the PrincipalInvestigator (PI) is allowed in the fellow eye only. IVT injections in the study eyeare prohibited.
3. History of uveitis or endophthalmitis
4. High myopia (more than 6 diopter) in the study eye
5. Any ocular pathology which would impede clear imaging of the macula, e.g. intra-ocularopacities
6. Macular changes from causes other than AMD
7. Diabetic retinopathy in either eye. Note: Presence of systemic diabetes with noretinopathy is not exclusionary
8. Any other physical condition which would prevent the participant from undertakingimaging procedures
9. Any cell or gene therapy in either eye