Phase
Condition
Retina
Geographic Atrophy
Eye Disease
Treatment
N/AClinical Study ID
Ages > 65 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Clinical diagnosis of bilateral GA due to AMD as confirmed by fundoscopy and imagingat Screening
GA lesion sizes of ≥ 1.25 mm2 to ≤ 17 mm2 (approximately 1-7 disc diameters) in atleast one eye as per Central Reading Center
Willing and able to provide written informed consent
Male or female aged 65 years and over
Exclusion
Exclusion Criteria:
History of neovascular (wet) AMD or presence of neovascular (wet) AMD in either eyeconfirmed by fundoscopy at screening and/or any pre-existing retinal imaging
History of intravitreal (IVT) injection in the study eye. Note: Intravitrealtreatment with pegcetacoplan (Syfovre®) and avacincaptad pegol (IzervayTM) ifapproved within the participant's country of origin AND if deemed necessary by thePrincipal Investigator (PI) is allowed in the fellow eye only. IVT injections in thestudy eye are prohibited.
History of uveitis or endophthalmitis
High myopia (more than 6 diopter) in the study eye
Any ocular pathology which would impede clear imaging of the macula, e.g.intra-ocular opacities
Macular changes from causes other than AMD
Diabetic retinopathy in either eye. Note: Presence of systemic diabetes with noretinopathy is not exclusionary
Any other physical condition which would prevent the participant from undertakingimaging procedures
Any cell or gene therapy in either eye
Study Design
Study Description
Connect with a study center
Belfast City Hospital
Belfast, BT9 7AB
United KingdomSite Not Available
Bradford Royal Infirmary
Bradford, BD9 6TB
United KingdomSite Not Available
Frimley Park Hospital
Frimley, GU16 7UJ
United KingdomSite Not Available
Gloucestershire Royal Hospital
Gloucester, GL1 3NN
United KingdomSite Not Available
Leicester Royal Infirmary
Leicester, LE1 5WW
United KingdomSite Not Available
Liverpool Hospital
Liverpool, L7 8XP
United KingdomSite Not Available
Moorfields Eye Hospital
London, EC1V 2PD
United KingdomSite Not Available
Western Eye Hospital
London, NW1 5QH
United KingdomSite Not Available
Manchester Royal Eye Hospital
Manchester, M13 9WL
United KingdomSite Not Available
Newcastle Hospital
Newcastle, NE1 4LP
United KingdomSite Not Available
Nottingham City Hospital
Nottingham, NG7 2UH
United KingdomSite Not Available
University Hospital Southampton
Southampton, SO16 6YD
United KingdomSite Not Available
Sunderland Eye Infirmary
Sunderland, SR2 9HP
United KingdomSite Not Available
Global Research Management
Glendale, California 91204
United StatesSite Not Available
Northern California Retina Vitreous Associates
Mountain View, California 94040
United StatesSite Not Available
Midwest Eye Institute
Carmel, Indiana 46290
United StatesSite Not Available
Mid Atlantic Retina Specialists
Hagerstown, Maryland 21740
United StatesSite Not Available
Sierra Eye Associates
Reno, Nevada 89506
United StatesSite Not Available
Verum Research LLC
Eugene, Oregon 97401
United StatesSite Not Available
Mid Atlantic Retina
Philadelphia, Pennsylvania 19610
United StatesSite Not Available
Retina Service of Wills Eye Hospital
Philadelphia, Pennsylvania 19107
United StatesSite Not Available
Retina Research Institute of Texas
Abilene, Texas 79606
United StatesSite Not Available
Texas Retina Associates
Plano, Texas 75075
United StatesSite Not Available
San Antonio Eye Center
San Antonio, Texas 78215
United StatesSite Not Available
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