Endovascular Treatment of Wide Neck Saccular Cerebral Aneurysms

Last updated: April 15, 2024
Sponsor: Sohag University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Aneurysm

Treatment

Endovascular procedure of treatment of wide neck saccular cerebral aneurysm

Clinical Study ID

NCT05796986
Soh-Med-23-03-02MD
  • All Genders

Study Summary

Intracranial aneurysm (IA) is a cerebrovascular disorder in which the weakness of a cerebral artery wall causes a localized dilation of the blood vessel. Intracranial aneurysm can develop and rupture, and about 85% of spontaneous subarachnoid hemorrhage (SAH) cases are caused by the rupture of Intracerebral aneurysm.

Two treatments are available globally: microsurgical clipping and endovascular treatment.

Endovascular treatment of Intracerebral aneurysms using detachable platinum coils ( was introduced in 1990 by Guido Guglielmi, an Italian neurosurgeon ) of different shapes and sizes are deposited into the aneurysm through a microcatheter, which reduces the blood flow and induces thrombus formation .

Wide neck aneurysm defined by neck diameter greater than 4 mm or dome-to-neck ratio less than 2 Despite advances in endovascular techniques , the treatment of wide-necked aneurysms remains problematic . Endovascular treatment of intracranial aneurysms is associated with lower morbidity and mortality rates and faster recovery compared with traditional microsurgical clipping.

In wide-necked Intracerebral aneurysms, complete coil embolization is often technically difficult owing to the risks of distal coil migration or coil impingement on the parent vessel .

Complete coil embolization using a single microcatheter without a supporting device in cases of wide-necked Intracerebral aneurysm is technically difficult. Total occlusion rates have increased recently as a result of the advancement of supporting devices These may include balloon remodeling, use of three-dimensional (3D) coils (Russian Doll Technique), combined use of stents and coils (Stent assisted coiling), flow diverters, use of intrasaccular flow disruption (like WEB), Double catheter Technique or combined extra- and intrasaccular devices.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • All patients of spontaneous subarachnoid haemorrhage due to ruptured wide necksaccular cerebral aneurysms
  • unruptured Denovo wide neck saccular cerebral aneurysms

Exclusion

Exclusion Criteria:

  • other forms of cerebral aneurysms rather than saccular type : fusiform and dissectinganeurysms
  • complex aneurysms : giant and thrombosed aneyrsms
  • any spontaneous subarachnoid haemorrhage with world fedriation of neurosurgerysocieties (WFNS) Grade 4&5
  • Any patient unfit for general anesethia or has serious renal impairment

Study Design

Total Participants: 40
Treatment Group(s): 1
Primary Treatment: Endovascular procedure of treatment of wide neck saccular cerebral aneurysm
Phase:
Study Start date:
January 01, 2022
Estimated Completion Date:
December 01, 2024

Connect with a study center

  • Sohag University Hospital

    Sohag,
    Egypt

    Active - Recruiting

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