Pimavanserin for Sleep in Parkinson Disease

Inclusion criteria:

1. Has a diagnosis of idiopathic PD according to UK (United Kingdom) PD Society Brain Bank diagnostic criteria

2. Has a history of hallucinations or delusions associated with PD

3. Has a history of sleep disturbance

4. Is between the ages of 40 and 85

5. Has been on a stable dose of all PD medications for at least 30 days prior to enrolment

Exclusion criteria

1. Has evidence of an atypical or secondary parkinsonian disorder

2. Has a contraindication to taking pimavanserin

3. Has contraindication to PSG

4. There has been a change to patient's neuropsychiatric medications including dopaminergic medications (Sinemet, dopamine agonists, MAO(monoamine oxidaze)-B inhibitors), SSRIs (Selective Serotonin Reuptake Inhibitors), SNRIs (Serotonin and Norepinephrine Reuptake Inhibitors), dopamine-blocking agents, anti-epileptics, anticholinergics, or benzodiazepines for at least 30 days prior to enrollment

5. Has traveled through 3 or more time zones within 60 days prior to study screening

6. Patient is a night-shift worker