Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)

Inclusion Criteria:

1. Patient is of legal age and skeletally mature

2. Patient is willing and able to provide written Informed Consent by signing anddating the Institutional Review Board (IRB) / Ethics Committee (EC) approvedInformed Consent document

3. Patient is willing and able to complete scheduled follow-up evaluations as definedin the study protocol

4. Independent of study participation, patient qualifies for either cemented orcementless primary or revision total knee arthroplasty (including salvage ofpreviously failed surgical attempts) based upon physical exam and medical history,and meets the approved indications for use of the commercially available PersonaKnee System with appropriately matched Zimmer Biomet components implanted inaccordance with product labeling

Exclusion Criteria:

1. Patient is currently participating in any other surgical intervention or painmanagement study

2. Patient is pregnant or considered a member of a protected (vulnerable) populationwhose inclusion in the study is inappropriate (e.g. prisoner, mentally incompetent)

3. Patient has a mental or neurological condition who is unwilling or incapable offollowing postoperative care instructions

4. Patient has a condition which would, in the judgment of the investigator, place thepatient at undue risk or interfere with the conduct of the study

5. Patient is institutionalized or is a known drug abuser, a known alcoholic or cannotunderstand the requirements of study participation

6. Patient is scheduled to undergo simultaneous bilateral total knee arthroplasty

7. Previous history of infection in the affected joint and/or other local/systemicinfection that may affect the prosthetic joint

8. Insufficient bone stock on femoral or tibial surfaces

9. Neuropathic arthropathy

10. Osteoporosis or any loss of musculature or neuromuscular disease that compromisesthe affected limb

11. A stable, painless arthrodesis in a satisfactory functional position

12. Severe instability secondary to the absence of collateral ligament integrity

13. Rheumatoid Arthritis (RA) accompanied by an ulcer of the skin or a history ofrecurrent breakdown of the skin

14. Patient has a > 5˚ valgus deformity with a medial collateral ligament (MCL)insufficiency, and the surgeon intends to use the personalized alignment surgicaltechnique