Efficacy and Safety of Dual-target DBS for Treatment-resistant Alcohol Use Disorder

Inclusion Criteria:

• 18 to 65 years old, no limit on sex.
• Qualifies DSM-5 definition of alcohol use diagnosis, at least more than 4 terms.
• Course of alcohol use disorder ≥ 3 years.
• Tried to quit drinking (de-addiction treatment under medical conditions, quit drinkingby oneself, quit drinking each time ≥ 1 week) but failed ≥ 3 times.
• Patient and relatives agree to accept systemic treatment of this study and signInformed Consent Form after study purpose, content, expected treatment and risk etc.are fully explained and understood.

Exclusion Criteria:

• Patients who qualify DSM-5 serious mental disorder diagnosis standard (e.g.Schizophrenia spectrum, depression disorder, biphasic or related disorder, etc. )
• Patients who have other substance (tobacco excluded) abuse.
• During screening period, answered 'yes' on question 4 or 5 in suicide intention termfrom Columbia-Suicide Severity Rating Scale, or had significant suicide intentions inthe past 3 months, or patients who are considered by researchers to have suicide orviolence risks.

4. Patients who have serious or unstable cardiovascular, respiratory, liver, kidney,hematological, endocrine, nervous system or other systemic diseases.

• Patients who have implanted cochlear, pacemaker, cardiac defibrillator, single-sidedor double-sided products of the same category, or the investigator evaluates patientshave done surgeries within 6 months that can affect this study.
• HIV positive patients.
• Woman at pregnant or lactation period, or childbearing age woman test positive forHCG/urine pregnancy check; or patients who can't take effective contraception measuresduring trial; or patients who plan to be/make pregnant 3 months after the trialstarts.
• Patients who are participating other pharmaceutical or medical device clinical trialsor have participated one in the past 3 months.
• Patients who are considered unsuitable by investigators.