SEARCH SAPPHIRE Phase B

Last updated: January 29, 2025
Sponsor: University of California, San Francisco
Overall Status: Active - Recruiting

Phase

N/A

Condition

Hiv

Treatment

Data system enhancement to improve reach and person-centered delivery

Standard of Care

Data-enhancement to improve precision of interventions

Clinical Study ID

NCT05768763
SEARCH SAPPHIRE Phase B
U01AI150510
  • Ages > 15
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This study will evaluate the effects of optimized dynamic prevention and treatment packages delivered in a precision community health model on HIV incidence, as well as other health outcomes, in a community randomized trial design.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Age >= 15 years

  2. Living in SEARCH study communities

  3. Provided informed consent

Exclusion

Exclusion Criteria:

  1. <15 years of age

  2. Living outside SEARCH study communities

  3. Unable to provide consent or parental co-consent as per country guidelines

Study Design

Total Participants: 80000
Treatment Group(s): 5
Primary Treatment: Data system enhancement to improve reach and person-centered delivery
Phase:
Study Start date:
March 28, 2023
Estimated Completion Date:
March 31, 2026

Study Description

In the "evaluation" Phase B, the SEARCH SAPPHIRE study will evaluate the effects of Dynamic Prevention and Dynamic Treatment intervention packages based on data from Phase A (NCT04810650) and new advances from outside the study delivered in a precision community health model, on HIV incidence and other health outcomes, in a pair-matched community randomized design.

The Phase B precision community health intervention will consist of a three part intervention: 1) Community-enhanced reach activities 2) Person-centered care delivery; and, 3) Data-enhancement to improve precision of interventions.

The study hypothesis for the Phase B population level study is: A Precision Community Health Model leveraging existing facility-based outreach and community health workers, enabled by dynamic choice prevention/treatment multi-disease approaches and interactive data systems -will reduce HIV infections, deaths and improve health.

Structured stakeholder consultations are formally incorporated in the study design and leverage regular and ongoing collaborations the study team has with the HIV, non-communicable disease and general health leads in Kenya and Uganda Ministries of Health and PEPFAR implementing partners at the national and the regional level.

Connect with a study center

  • SEARCH Office / GPRT

    Kisumu,
    Kenya

    Active - Recruiting

  • Infectious Diseases Research Collaboration

    Kampala,
    Uganda

    Active - Recruiting

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