Long-term Efficacy and Safety of Tozorakimab in Participants With Chronic Obstructive Pulmonary Disease With a History of Exacerbations (PROSPERO).

Inclusion Criteria:

1. Participants who have completed the treatment period and have not been prematurelydiscontinued from IP in the predecessor studies.

2. Participants who received their last dose of IP in the predecessor studies withinthe previous 12 weeks and were not withdrawn from the predecessor study.

3. FOCBP (female(s) of childbearing potential) must have a negative urine pregnancytest at Visit 1.

4. Participants who are willing to continue using contraceptive methods as agreed tofor the predecessor OBERON or TITANIA studies.

5. Capable of giving signed informed consent.

Exclusion Criteria:

1. Any clinically significant disorder or abnormal findings (clinical, laboratory,instrumental, etc) or major physical and/or cognitive impairment - which, in theopinion of the Investigator, may put the participant at risk because of his/herparticipation in the study or impact the interpretation of the study results, orotherwise make the participation of the participant inappropriate.

2. Participant meeting criteria for IP discontinuation as judged by the Investigator orthe Sponsor.

3. Concurrent enrolment in other interventional clinical studies or treatment withanother IP, with the exception of the OBERON and TITANIA predecessor studies.

4. Known history of:

5. Severe allergic reaction to any monoclonal and polyclonal antibody.

6. Allergy or reaction to any component of the IP formulation.

7. Chronic use (or expected need for chronic use during the study) of immunosuppressivemedications (including, but not limited to, systemic corticosteroids), marketed orinvestigational biologic, or another prohibited medication.

8. Involvement in the planning and/or conduct of the study (applies to both staffemployed by the Sponsor and/or staff at the study site).

9. Participants who are not able to comply with the study requirements, procedures, andrestrictions.