Prognosis of Cerebral Small Vessel Disease

Last updated: March 6, 2023
Sponsor: University Hospital Inselspital, Berne
Overall Status: Active - Recruiting

Phase

N/A

Condition

Alzheimer's Disease

Amyloidosis

Neurologic Disorders

Treatment

N/A

Clinical Study ID

NCT05734378
2020-02535
  • Ages > 16
  • All Genders

Study Summary

Prognosis of small vessel disease (SVD) depends on the underlying type of SVD and index manifestation.

The aim of this prospective, observational cohort study is to determine the risk of different outcome events among patients with SVD according to the type of index presentation.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Hypertensive deep perforator arteriolopathy (DPA), clinically symptomatic with eitherICH, ischaemic stroke, cognitive impairment or severe radiological manifestation (Fazekas ≥II)
  • Cerebral amyloid angiopathy (CAA according to modified Boston or Edinburgh criteria),clinically symptomatic with either ICH (including cSAH), amyloid spells, cognitiveimpairment or severe radiological manifestation (CMB≥2)
  • Other SVD (i.e. CADASIL or other sporadic or genetic SVD)

Exclusion

Exclusion Criteria:

  • Life expectancy of <6 months due to not-SVD related causes (i.e. cancer)
  • Patient is unlikely to attend follow-up visits

Study Design

Total Participants: 900
Study Start date:
December 01, 2020
Estimated Completion Date:
November 30, 2030

Connect with a study center

  • Department of Neurology, Inselspital Bern University Hospital

    Bern, 3010
    Switzerland

    Active - Recruiting

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